oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study
Department of Epidemiology and Public Health, University College London, London, UK.
Örebro University, School of Medical Sciences. Clinical Epidemiology and Biostatistics.ORCID iD: 0000-0002-2088-0530
Department of Health and Social Behavior, School of Public Health, University of Tokyo, Tokyo, Japan.
Division of International and Community Oral Health, Graduate School of Dentistry, Tohoku University, Miyagi, Japan.
Show others and affiliations
2018 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 5362948Article in journal (Refereed) Published
Abstract [en]

We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22-3.23; RRR = 1.36, 95% CI = 1.33-1.39; RRR = 1.36, 95% CI = 1.23-1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91-2.70; RRR = 1.59, 95% CI = 1.51-1.68; RRR = 1.40, 95% CI = 1.28-1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23-2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2018. article id 5362948
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:oru:diva-64827DOI: 10.1155/2018/5362948ISI: 000422965600001OAI: oai:DiVA.org:oru-64827DiVA, id: diva2:1180579
Note

Funding Agencies:

UK Economic and Social Research Council (ESRC)  ES/J019119/1 

Research Committee of Orebro County Council  OLL-346981 

MEXT (Ministry of Education, Culture, Sports, Science and Technology, Japan) Supported Program for the Strategic Research Foundation at Private Universities  

JSPS (Japan Society for the Promotion of Science) KAKENHI  JP22330172  JP22390400  JP23243070  JP23590786  JP23790710  JP24390469  JP24530698  JP24683018  JP25253052  JP25870573  JP25870881 

Health Labour Sciences Research Grants from the Japan Ministry of Health, Labour and Welfare  H22-Choju-Shitei-008  H24-Junkanki[Seishu]-Ippan-007  H24-Chikyukibo-Ippan-009  H24-Choju-Wakate-009  H25-Kenki-Wakate-015  H26-Irryo-Shitei-003[Fukkou]  H25-Choju-Ippan-003  H26-Choju-Ippan-006 

Research and Development Grants for Longevity Science from AMED (Japan Agency for Medical Research and Development)  

National Centre for Geriatrics and Gerontology, Japan  24-17  24-23 

Available from: 2018-02-06 Created: 2018-02-06 Last updated: 2018-02-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Hiyoshi, Ayako

Search in DiVA

By author/editor
Hiyoshi, Ayako
By organisation
School of Medical Sciences
In the same journal
BioMed Research International
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 41 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf