Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation StudyShow others and affiliations
2018 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 5362948
Article in journal (Refereed) Published
Abstract [en]
We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22-3.23; RRR = 1.36, 95% CI = 1.33-1.39; RRR = 1.36, 95% CI = 1.23-1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91-2.70; RRR = 1.59, 95% CI = 1.51-1.68; RRR = 1.40, 95% CI = 1.28-1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23-2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.
Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2018. article id 5362948
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:oru:diva-64827DOI: 10.1155/2018/5362948ISI: 000422965600001Scopus ID: 2-s2.0-85041725243OAI: oai:DiVA.org:oru-64827DiVA, id: diva2:1180579
Note
Funding Agencies:
UK Economic and Social Research Council (ESRC) ES/J019119/1
Research Committee of Orebro County Council OLL-346981
MEXT (Ministry of Education, Culture, Sports, Science and Technology, Japan) Supported Program for the Strategic Research Foundation at Private Universities
JSPS (Japan Society for the Promotion of Science) KAKENHI JP22330172 JP22390400 JP23243070 JP23590786 JP23790710 JP24390469 JP24530698 JP24683018 JP25253052 JP25870573 JP25870881
Health Labour Sciences Research Grants from the Japan Ministry of Health, Labour and Welfare H22-Choju-Shitei-008 H24-Junkanki[Seishu]-Ippan-007 H24-Chikyukibo-Ippan-009 H24-Choju-Wakate-009 H25-Kenki-Wakate-015 H26-Irryo-Shitei-003[Fukkou] H25-Choju-Ippan-003 H26-Choju-Ippan-006
Research and Development Grants for Longevity Science from AMED (Japan Agency for Medical Research and Development)
National Centre for Geriatrics and Gerontology, Japan 24-17 24-23
2018-02-062018-02-062023-12-08Bibliographically approved