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Prenatal phthalate exposure was associated with croup in Swedish infants
Dept. of Health Sciences, Karlstad University, Sweden.
Örebro University, School of Medical Sciences.
Division of Occupational and Environmental Medicine, Lund University, Sweden.
Division of Occupational and Environmental Medicine, Lund University, Sweden.
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2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, no 6, p. 1011-1019Article in journal (Refereed) Published
Abstract [en]

AIM: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants.

METHODS: From 2007-2010 we used liquid chromatography tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1,062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders.

RESULTS: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1,062 infants during the first year of life, when adjusted for potential confounders. A dose response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life.

CONCLUSION: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 107, no 6, p. 1011-1019
Keywords [en]
Croup, Exposure, Phthalate, Pregnant, SELMA study
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-64845DOI: 10.1111/apa.14245ISI: 000431956700017PubMedID: 29385277Scopus ID: 2-s2.0-85046728033OAI: oai:DiVA.org:oru-64845DiVA, id: diva2:1181009
Funder
Swedish Research Council FormasSwedish Asthma and Allergy Association
Note

Funding Agencies:

Swedish Foundation for Health Care Sciences and Allergy Research  

County Council of Värmland 

Available from: 2018-02-07 Created: 2018-02-07 Last updated: 2018-05-24Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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