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The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
Linköping University, Linköping, Sweden.
Örebro University, School of Medical Sciences. Department of Urology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Clinic Boris, Kyiv, Ukraine.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, no 1, article id 2268Article in journal (Refereed) Published
Abstract [en]

We have earlier found abnormal expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) in endometrial cancer, compared to the expression in hyperplasia and in normal endometrium. Here we report that expression of S18-2 was increased with disease progression in clinical specimens of prostate cancer (PCa). The level of induction of epithelial to mesenchymal cell transition (EMT) correlated with the expression level of S18-2 in PCa cell lines. Moreover, cells acquired increased ability of migration upon S18-2 overexpression, as was evaluated in zebrafish embryo model and in trans-well assay. We found that this is due to increased CXCR4 cell surface expression. Neutralizing CXCR4 protein or abrogating S18-2 expression in cells significantly reduced their migratory ability directed toward CXCL12. The mRNA expression of TWIST2, encoding one of transcription factors that induce EMT upon CXCR4 increase, positively correlated with the S18-2 protein level. Together, these data suggest that the S18-2 protein induces EMT through the TWIST2/E-cadherin signalling and, consequently, CXCR4-mediated migration of PCa cells.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, no 1, article id 2268
National Category
Cancer and Oncology Urology and Nephrology
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URN: urn:nbn:se:oru:diva-64841DOI: 10.1038/s41598-018-20765-8PubMedID: 29396484Scopus ID: 2-s2.0-85041612784OAI: oai:DiVA.org:oru-64841DiVA, id: diva2:1181113
Available from: 2018-02-07 Created: 2018-02-07 Last updated: 2018-09-05Bibliographically approved

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Davidsson, SabinaAndrén, Ove

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