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Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels
Örebro University, School of Health Sciences.ORCID iD: 0000-0003-3793-335X
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-1767-9297
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-9831-0896
2018 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 50, no 7, p. 1502-1507Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To examine the influence of reallocating time spent at different objectively measured physical activity (PA) behaviours on markers of systemic inflammation in older women with different levels of metabolic risk.

METHODS: Accelerometer-based monitoring of PA was conducted in a population of community-dwelling older women (n = 111; age = 65-70 yr) for determination of daily sedentary time, time in light (LPA) and moderate-to-vigorous physical activity (MVPA). Blood samples were collected for the assessment of the systemic inflammatory markers CRP, fibrinogen and adiponectin. Metabolic risk was assessed by standardized procedures based on definitions for the metabolic syndrome. Data were analysed by linear regression models based on isotemporal substitution analysis.

RESULTS: Reallocating 30 minutes of sedentary time with either time in LPA (β = -0.47; p<0.05) or MVPA (β = -0.42; p<0.05) was related to reduced fibrinogen level, whereas no corresponding effect was evident when shifting time in LPA with time in MVPA, while holding sedentary time constant. In contrast, reallocating a 30-minute time period in sedentary (β = -0.70; p<0.01) or LPA (β = -0.71; p<0.01) with MVPA was associated with a significant reduction in CRP level, while no impact on CRP was observed when a time period of sedentary behavior was replaced with LPA. Importantly, all significant influences on fibrinogen and CRP by displacement of different PA behaviours remained after adjustment for metabolic risk status among participants. No significant associations with adiponectin were observed.

CONCLUSION: Altogether, this work supports the existence of different intensity thresholds mediating beneficial effects of PA on important clinical markers of systemic inflammation in older women across different stages of disease prevention.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018. Vol. 50, no 7, p. 1502-1507
Keywords [en]
EXERCISE TRAINING, ELDERLY, ISOTEMPORAL, SEDENTARY BEHAVIOR, METABOLIC RISK, ACUTE PHASE PROTEIN
National Category
Occupational Health and Environmental Health Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:oru:diva-65195DOI: 10.1249/MSS.0000000000001582ISI: 000435348900020PubMedID: 29462102Scopus ID: 2-s2.0-85045633896OAI: oai:DiVA.org:oru-65195DiVA, id: diva2:1185274
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2022-08-26Bibliographically approved
In thesis
1. Chronic Systemic Inflammation, Body Composition and Physical Activity Behaviours in Older Adults
Open this publication in new window or tab >>Chronic Systemic Inflammation, Body Composition and Physical Activity Behaviours in Older Adults
2022 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Ageing is associated with a gradual physical decline accompanied by changes in body composition. The occurrence of a low-grade yet chronic state of systemic inflammation has gained interest for its potential consequences in the ageing process. Importantly, a physically active lifestyle may promote the maintenance of muscle mass, reduction in adipose tissue, and alleviate progression of a chronic pro-inflammatory state. 

The overall aim of this thesis was to explore relationships between biomarkers of systemic inflammation, body composition, and physical activity behaviours in community-dwelling older adults aged 65 to 70 years.

A main finding of the thesis is the existence of associations between body composition and systemic inflammation in older adults, where excess adipose tissue is adversely associated with levels of inflammatory biomarkers in older women. Inverse associations were also observed between muscle mass and levels of pro-inflammatory biomarkers in older women. This thesis also highlights sex-specific associations between systemic inflammation and physical activity behaviours. Longer time spent sedentary was also associated with higher levels of proinflammatory biomarkers in older women and lower level of antiinflammatory biomarkers in older men. Reallocating time spent in activities of lower intensities with higher intensities was associated with lower levels of pro-inflammatory biomarkers in older women. 

Overall, the findings of this thesis support efforts promoting physical activity at the expense of sedentary time in order to combat age-related systemic inflammation and metabolic risk in older adults.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2022. p. 101
Series
Örebro Studies in Sport Sciences, ISSN 1654-7535 ; 36
Keywords
Ageing, Exercise, Sedentary behaviour, Adipose tissue, Muscle mass, Muscle strength, Inflammatory biomarkers, Cardiorespiratory fitness, Metabolic health
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-96015 (URN)9789175294230 (ISBN)
Public defence
2022-03-04, Örebro universitet, Långhuset, Hörsal L2, Fakultetsgatan 1, Örebro, 09:00 (English)
Opponent
Supervisors
Available from: 2021-12-15 Created: 2021-12-15 Last updated: 2022-02-16Bibliographically approved

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Nilsson, AndreasBergens, OscarKadi, Fawzi

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