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The familial aggregation of atopic diseases and depression or anxiety in children
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia.
Örebro University, School of Medical Sciences. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
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2018 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 48, no 6, p. 703-711Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Children with asthma and atopic diseases have an increased risk of depression or anxiety. Each of these diseases have strong genetic and environmental components, therefore it seems likely that there is a shared liability rather than causative risk.

OBJECTIVE: To investigate the existence and nature of familial aggregation for the comorbidity of atopic diseases and depression or anxiety.

METHODS: Participants came from the Childhood and Adolescent Twin Study in Sweden (CATSS), n= 14197. Current and ever asthma, eczema, hayfever and food-allergy were reported by parents. Internalizing disorders were identified using validated questionnaires. Familial co-aggregation analysis compared monozygotic MZ twins and same-sex dizygotic DZ twins for atopic disease in one twin with internalizing disorder in the other to test for genetic liability. Several familial liability candidates were also tested including parental education, recent maternal psychological stress, childhood family trauma and parental country of birth.

RESULTS: Familial co-aggregation analysis found that if one twin had at least one current atopic disease the partner twin was at risk of having an internalizing disorder regardless of their own atopic status (Adjusted OR 1.22 (95% CI 1.08, 1.37). Similar results were found for each atopic disease ever and current. MZ associations were not higher than DZ associations suggesting that the liability is not genetic in nature. Including other familial candidates to the models made little difference to effect estimates.

CONCLUSIONS AND CLINICAL RELEVANCE: Atopic diseases and depression or anxiety tend to occur together in families, therefore when treating for one disease the physician should consider comorbidity in both the individual and the individual's siblings. We did not find evidence to support a genetic explanation for comorbidity and further exploration is needed to disentangle the environmental and epigenetic reasons for familial aggregation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 48, no 6, p. 703-711
Keywords [en]
anxiety, asthma, atopic dermatitis, child, depression, eczema, food allergy, rhinitis
National Category
Psychiatry Immunology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-65571DOI: 10.1111/cea.13127ISI: 000434080100010PubMedID: 29513367Scopus ID: 2-s2.0-85044637271OAI: oai:DiVA.org:oru-65571DiVA, id: diva2:1188732
Funder
Swedish Heart Lung FoundationSwedish Asthma and Allergy AssociationForte, Swedish Research Council for Health, Working Life and Welfare, 2015-00289
Note

Funding Agencies:

Swedish Research Council through the Swedish Initiative for research on Microdata in the Social And Medical sciences (SIMSAM) framework  340-2013-5867

Stockholm County Council (ALF project)

COFAS Marie Curie Fellowship  2015-01208

Available from: 2018-03-08 Created: 2018-03-08 Last updated: 2018-06-20Bibliographically approved

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