Monitoring of environmental contaminants in biological samples is typically performed by targeted analysis using a tandem quadrupole system on separate GC and LC platforms in order to cover the expansive range of compounds. Use of multiple systems can add complexity to the analysis and increase turnaround times for samples to be reported. The work that will be presented will show the analysis of common environmental contaminants in a biomonitoring context on a single high resolution mass spectrometric (HRMS) platform. The compounds of interest include: