oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Novel methodologies in metabolic profiling with a focus on molecular diagnostic applications
VTT Technical Research Centre of Finland, Espoo, Finland.
2012 (English)In: Expert Review of Molecular Diagnostics, ISSN 1473-7159, E-ISSN 1744-8352, Vol. 12, no 5, p. 527-538Article in journal (Refereed) Published
Abstract [en]

The metabolome contains all the biological end points of genomic, transcriptomic and proteomic perturbations, also including the influence of gut microbiota and the environment, giving a direct picture of an organism's ongoing metabolic state. Metabolomics thus has the potential to be an effective tool for early diagnosis of disease, and also to be a predictor of treatment response and survival. In recent years, the development of instrumental systems has enabled more comprehensive coverage of the metabolome. Advances in mass spectrometry and chromatography have particularly improved both the efficiency of nontargeted metabolic profiling as well as the sensitivity and reliability of targeted analyses. Mass spectrometric techniques are also increasingly becoming accepted as a routine diagnostic tool in clinical laboratories. This review summarizes the most recent advances and current challenges in metabolomics, with a focus on mass spectrometric methods utilized in biomarker research, highlighted with selected examples.

Place, publisher, year, edition, pages
Taylor & Francis, 2012. Vol. 12, no 5, p. 527-538
Keywords [en]
biomarkers; chromatography; diagnostics; mass spectrometry; metabolomics
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-65694DOI: 10.1586/erm.12.33ISI: 000306542000017PubMedID: 22702368Scopus ID: 2-s2.0-84862516904OAI: oai:DiVA.org:oru-65694DiVA, id: diva2:1189755
Available from: 2018-03-12 Created: 2018-03-12 Last updated: 2018-03-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Hyötyläinen, Tuulia

Search in DiVA

By author/editor
Hyötyläinen, Tuulia
In the same journal
Expert Review of Molecular Diagnostics
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 43 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf