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Optimizing the lipidomics workflow for clinical studies: practical considerations
Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Turku, Finland; Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland.
Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Turku, Finland; Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland.ORCID iD: 0000-0002-2856-9165
2015 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 407, no 17, p. 4973-4993, article id 8633Article, review/survey (Refereed) Published
Abstract [en]

Lipidomics is increasingly being used in clinical research, offering new opportunities for disease prediction and detection. One of the key challenges of clinical applications of lipidomics is the high sensitivity of measured lipid levels to many analytical, physiological, and environmental factors, which therefore must be taken into account when designing the studies. Here we critically discuss the complete clinical lipidomics workflow, including selection of the subjects, the sample type, the sample preprocessing conditions, and the analytical method and methods for data processing. We also review the lipidomics applications which investigate the confounding factors such as age, gender, fasting time, and handling procedures for measuring blood lipid metabolites.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 407, no 17, p. 4973-4993, article id 8633
Keywords [en]
Biomarkers, Lipidomics, Mass spectrometry, Metabolomics, Systems biology, Systemsmedicine
National Category
Medical and Health Sciences Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-65678DOI: 10.1007/s00216-015-8633-2ISI: 000356461800010PubMedID: 25855150Scopus ID: 2-s2.0-84938085227OAI: oai:DiVA.org:oru-65678DiVA, id: diva2:1189779
Funder
Academy of Finland, 250114EU, FP7, Seventh Framework Programme, 279228
Note

Cited By :18; Export Date: 12 March 2018; Article

Available from: 2018-03-12 Created: 2018-03-12 Last updated: 2018-07-09Bibliographically approved

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Hyötyläinen, TuuliaOresic, Matej

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