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Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
Örebro University, School of Medical Sciences. Centre for Clinical Research, Hospital of Västmanland Västerås, Region Västmanland, Västerås, Sweden; Centre for Clinical Research, Hospital of Västmanland Västerås, Uppsala University, Västerås, Sweden. (iRiSC - Inflammatory Response and Infection Susceptibility Centre)ORCID iD: 0000-0003-2867-1044
Örebro University, Örebro, Sweden. (iRiSC - Inflammatory Response and Infection Susceptibility Centre)
Department of Infectious Diseases, and Department of Clinical and Experimental Medicine, Linköping University, Norrköping, Sweden.
Örebro University, School of Medical Sciences. (iRiSC - Inflammatory Response and Infection Susceptibility Centre)ORCID iD: 0000-0002-4319-7208
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2018 (English)In: Journal of bone and joint infection, ISSN 2206-3552, Vol. 3, no 1, p. 10-14Article in journal (Refereed) Published
Abstract [en]

Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.

Place, publisher, year, edition, pages
IVYSPRING , 2018. Vol. 3, no 1, p. 10-14
Keywords [en]
Staphylococcus epidermidis, caspase-1, neutrophils, prosthetic joint infections, host-pathogen interaction
National Category
Medical and Health Sciences Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-65927DOI: 10.7150/jbji.21567PubMedID: 29545990OAI: oai:DiVA.org:oru-65927DiVA, id: diva2:1191978
Available from: 2018-03-21 Created: 2018-03-21 Last updated: 2018-09-04Bibliographically approved

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Månsson, EmeliSärndahl, EvaSöderquist, Bo

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CiteExportLink to record
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