oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
An extra priming dose of hepatitis A vaccine to adult patients with rheumatoid arthritis and drug induced immunosuppression: A prospective, open-label, multi-center study
Örebro University, School of Medical Sciences. Dept. of Infectious Diseases, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland .
Institute of Virology, Technical University of Munich / Helmholtz Zentrum München, Munich, Germany.
Örebro University, School of Medical Sciences. Dept. of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden.
Show others and affiliations
2018 (English)In: Travel Medicine and Infectious Disease, ISSN 1477-8939, E-ISSN 1873-0442, Vol. 21, p. 43-50Article in journal (Refereed) Published
Abstract [en]

Background: Previous studies have indicated that a pre-travel single dose of hepatitis A vaccine is not sufficient as protection against hepatitis A in immunocompromised travelers. We evaluated if an extra dose of hepatitis A vaccine given shortly prior to traveling ensures seroconversion.

Method: Patients with rheumatoid arthritis (n = 69, median age = 55 years) treated with Tumor Necrosis Factor inhibitor(TNFi) and/or Methotrexate (MTX) were immunized with two doses of hepatitis A vaccine, either as double dose or four weeks apart, followed by a booster dose at six months. Furthermore, 48 healthy individuals, median age = 60 years were immunized with two doses, six months apart. Anti-hepatitis A antibodies were measured at 0, 1, 2, 6, 7 and 12 months.

Results: Two months after the initial vaccination, 84% of the RA patients had protective antibodies, compared to 85% of the healthy individuals. There was no significant difference between the two vaccine schedules. At twelve months, 99% of RA patients and 100% of healthy individuals had seroprotective antibodies.

Conclusion: An extra priming dos of hepatitis A vaccine prior to traveling offered an acceptable protection in individuals treated with TNFi and/or MTX. This constitutes an attractive pre-travel solution to this vulnerable group of patients.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 21, p. 43-50
Keywords [en]
Hepatitis A, Vaccine, Rheumatoid arthritis, Immunosuppression, Methotrexate, TNF-Inhibitors
National Category
Public Health, Global Health, Social Medicine and Epidemiology Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-65919DOI: 10.1016/j.tmaid.2017.12.004ISI: 000426614600006PubMedID: 29229311Scopus ID: 2-s2.0-85037718947OAI: oai:DiVA.org:oru-65919DiVA, id: diva2:1192041
Note

Funding Agencies:

Uppsala-Örebro Regional Research Council  RFR-30790 

Regional Research committee of Örebro lan  OLL-259611  OLL-459691 OLL-671751 

Scandinavian Society for Antimicrobial Chemotherapy Foundation  SLS-171941 

Available from: 2018-03-21 Created: 2018-03-21 Last updated: 2018-10-18Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopusCorrigendum

Authority records BETA

Rosdahl, AnjaNorén, Torbjörn

Search in DiVA

By author/editor
Rosdahl, AnjaNorén, Torbjörn
By organisation
School of Medical Sciences
In the same journal
Travel Medicine and Infectious Disease
Public Health, Global Health, Social Medicine and EpidemiologyInfectious Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 69 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf