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Platelet Function Determined by Flow Cytometry: New Perspectives?
Linköping University, Linköping, Sweden.ORCID iD: 0000-0002-1920-3962
Linköping University, Linköping, Sweden.ORCID iD: 0000-0003-0460-4744
Linköping University, Linköping, Sweden.
Linköping University, Linköping, Sweden.
2016 (English)In: Seminars in Thrombosis and Hemostasis, ISSN 0094-6176, E-ISSN 1098-9064, Vol. 42, no 3, p. 268-281Article, review/survey (Refereed) Published
Abstract [en]

Flow cytometry enables studies of several different aspects of platelet function in response to a variety of platelet agonists. This can be done using only a small volume of whole blood, and also in blood with low platelet counts. These properties, together with the increasing number of flow cytometers available in hospitals worldwide, make flow cytometry an interesting option for laboratories interested in studies of platelet function in different clinical settings. This review focuses on practical issues regarding the use of flow cytometry for platelet function testing. It provides an overview of available activation markers, platelet agonists, and experimental setup issues. The review summarizes previous experience and factors important to consider to perform high-quality platelet function testing by flow cytometry. It also discusses its current use and possibilities and challenges for future use of flow cytometry in clinical settings.

Place, publisher, year, edition, pages
Thieme Medical Publishers, 2016. Vol. 42, no 3, p. 268-281
Keyword [en]
Blood platelets, flow cytometry, platelet activation, platelet function testing
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:oru:diva-66026DOI: 10.1055/s-0035-1570082ISI: 000373139300011PubMedID: 26886398Scopus ID: 2-s2.0-84958780744OAI: oai:DiVA.org:oru-66026DiVA, id: diva2:1192607
Available from: 2018-03-22 Created: 2018-03-22 Last updated: 2018-04-09Bibliographically approved

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Ramström, Sofia

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