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Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients
Umeå University, Umeå, Sweden.ORCID iD: 0000-0001-9215-4047
Umeå University, Umeå, Sweden.
Umeå University, Umeå, Sweden.
Umeå University, Umeå, Sweden.
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2015 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 212, no 7, p. 1061-1069Article in journal (Refereed) Published
Abstract [en]

Background: Thrombocytopenia is a common finding during viral hemorrhagic fever, which includes hemorrhagic fever with renal syndrome (HFRS). The 2 main causes for thrombocytopenia are impaired thrombopoiesis and/or increased peripheral destruction of platelets. In addition, there is an increased intravascular coagulation risk during HFRS, which could be due to platelet activation.

Methods: Thrombopoiesis was determined by quantification of platelet counts, thrombopoietin, immature platelet fraction, and mean platelet volume during HFRS. The in vivo platelet activation was determined by quantification of soluble P-selectin (sP-selectin) and glycoprotein VI (sGPVI). The function of circulating platelets was determined by ex vivo stimulation followed by flow cytometry analysis of platelet surface-bound fibrinogen and P-selectin exposure. Intravascular coagulation during disease was determined by scoring for disseminated intravascular coagulation (DIC) and recording thromboembolic complications.

Results: The levels of thrombopoietin, immature platelet fraction, and mean platelet volume all indicate increased thrombopoiesis during HFRS. Circulating platelets had reduced ex vivo function during disease compared to follow-up. Most interestingly, we observed significantly increased in vivo platelet activation in HFRS patients with intravascular coagulation (DIC and thromboembolic complications) as shown by sP-selectin and sGPVI levels. Conclusions. HFRS patients have increased thrombopoiesis and platelet activation, which contributes to intravascular coagulation.

Place, publisher, year, edition, pages
Oxford University Press, 2015. Vol. 212, no 7, p. 1061-1069
Keyword [en]
Disseminated intravascular coagulation, hantavirus, hemorrhagic fever with renal syndrome, platelets, thrombosis, viral hemorrhagic fever
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:oru:diva-66030DOI: 10.1093/infdis/jiv161ISI: 000363191300007PubMedID: 25762786Scopus ID: 2-s2.0-84942914330OAI: oai:DiVA.org:oru-66030DiVA, id: diva2:1192612
Available from: 2018-03-22 Created: 2018-03-22 Last updated: 2018-04-04Bibliographically approved

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Connolly-Andersen, Anne-MarieBaudin, MariaDunne, EimearKenny, DermotRamström, Sofia
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