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Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men: A randomized controlled trial
Örebro University, School of Medical Sciences.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-1440-9961
Örebro University, School of Medical Sciences.
Örebro University, School of Medical Sciences.
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(English)Manuscript (preprint) (Other academic)
National Category
General Practice
Identifiers
URN: urn:nbn:se:oru:diva-66214OAI: oai:DiVA.org:oru-66214DiVA, id: diva2:1193970
Available from: 2018-03-28 Created: 2018-03-28 Last updated: 2018-11-06Bibliographically approved
In thesis
1. Vitamin D and its role in obesity and other associated conditions
Open this publication in new window or tab >>Vitamin D and its role in obesity and other associated conditions
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Vitamin D has received much attention in recent years due to the re-emergence of vitamin D deficiency as a global health issue along with increasing evidence indicating that 1,25-dihydroxivitamin D, the hormonally active form of vita-min D, not only acts in calcium and bone metabolism but also generates ex-traskeletal biological responses.

In this thesis, the role of vitamin D in obesity and other associated condi-tions has been studied.

In paper 1, the prevalence of vitamin D deficiency and secondary hyperpara-thyroidism over the long term after Roux-en-Y gastric bypass (RYGB) were evaluated. We found a substantial prevalence of vitamin D deficiency and secondary hyperparathyroidism after RYGB, whereas calcium levels remained within normal range. An expected improvement in vitamin D status after weight loss could have been countered by the malabsorption induced by surgery.

In paper 2, the prevalence of anemia and related deficiencies over the long term after RYGB were studied. We found that 27% of the patients had anemia postoperatively, 20% had iron deficiency, 12% had folate deficiency and 2% had vitamin B12 deficiency. Anemia was mainly due to iron deficiency, and its frequency did not seem to progress with time after surgery.

In paper 3, the effects of vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men with vitamin D deficiency at baseline were investigated. No statistically significant difference between the placebo and the intervention group regarding changes in percentage body fat, maximum oxygen uptake, BMI and maximum load was found.

In paper 4, the prevalence and determinants of 3-epi-25(OH)D3 were exam-ined. 3-epi-25(OH)D3 was detected in 7.7% of the study population and the mean concentration was 8.4 nmol/L. The quantification of 3-epi-25(OH)D3 would not significantly influence the clinical interpretation of vitamin D levels.

In conclusion, new knowledge about vitamin D is continuously emerging but there is a discrepancy between cross-sectional studies associating low vitamin D levels to obesity and other related metabolic complications and the lack of effects of vitamin D supplementation in clinical trials. Large RCTs with longer duration in obese subjects with baseline vitamin D deficiency are warranted.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2018. p. 67
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 177
Keywords
Vitamin D, obesity, Roux-en-Y gastric bypass, secondary hyperpara-thyroidism, anemia, iron deficiency, body composition, cardiorespiratory fitness, Vitamin D C3 epimer
National Category
General Practice
Identifiers
urn:nbn:se:oru:diva-64979 (URN)978-91-7529-238-0 (ISBN)
Public defence
2018-04-20, Örebro universitet, Campus USÖ, hörsal C3, Södra Grev Rosengatan 32, Örebro, 13:00 (Swedish)
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Available from: 2018-02-12 Created: 2018-02-12 Last updated: 2018-11-06Bibliographically approved

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Karefylakis, ChristosSärnblad, StefanRask, EvaRask, Peter

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