Celiac disease and risk of myasthenia gravis - nationwide population-based studyShow others and affiliations
2018 (English)In: BMC Neurology, E-ISSN 1471-2377, Vol. 18, article id 28
Article in journal (Refereed) Published
Abstract [en]
Background: Case reports suggest there may be an association between celiac disease (CD) and myasthenia gravis (MG).
Methods: We identified 29,086 individuals with CD in Sweden from 1969 to 2008. We compared these individuals with 144,480 matched controls. Hazard ratios (HRs) for future MG (identified through ICD codes) were estimated using Cox regression.
Results: During 326,376 person-years of follow-up in CD patients, there were 7 MG cases (21/million person-years) compared to 22 MG cases in controls during 1,642,273 years of follow-up (14/million person-years) corresponding to a HR of 1.48 (95% CI = 0.64-3.41). HRs did not differ when stratifying for age, sex or calendar period. HRs were highest in the first year after follow-up, though insignificant. Individuals with CD were at no increased risk of MG more than 5 years after CD diagnosis (HR = 0.70; 95% CI = 0.16-3.09).
Conclusion: This study found no increased risk of MG in patients with CD.
Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2018. Vol. 18, article id 28
Keywords [en]
Autoimmune, Celiac, Gluten, Myasthenia gravis
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-66265DOI: 10.1186/s12883-018-1035-2ISI: 000427138100001PubMedID: 29529996Scopus ID: 2-s2.0-85043477669OAI: oai:DiVA.org:oru-66265DiVA, id: diva2:1194568
Funder
Swedish Society of MedicineSwedish Research Council
Note
Funding Agency:
National Center for Advancing Translational Sciences, National Institutes of Health UL1 TR000040
2018-04-032018-04-032022-02-10Bibliographically approved