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Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3- and 5-year follow-up
Department of Molecular Periodontology, Umeå University, Umeå, Sweden; Department of Periodontology, Gävle County Hospital, Public Dental Health County Council of Gävleborg, Gävle, Sweden; Center for Research and Development, Region Gävleborg, Uppsala University, Gävle, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Postgraduate Dental Education Center, Region Örebro County, Örebro, Sweden.
Department of Molecular Periodontology, Umeå University, Umeå, Sweden.
Department of Periodontology, Gävle County Hospital, Public Dental Health County Council of Gävleborg, Gävle, Sweden; Center for Research and Development, Region Gävleborg, Uppsala University, Gävle, Sweden.
2018 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 45, no 6, p. 744-753Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To assess the clinical and radiographic outcomes 3 and 5 years after the surgical treatment of peri-implantitis per se or in combination with an enamel matrix derivative (EMD).

MATERIALS AND METHODS: At baseline, 29 patients were randomized to surgical treatment with adjunctive EMD or no EMD. One year after the surgical treatment of peri-implantitis, 25 patients remained eligible for survival analyses at the 3- and 5-year follow-up. The primary outcomes were implant loss and bone level (BL) change measured on radiographs, and the secondary outcomes, bleeding on probing, pus and plaque at each implant, were analyzed in 18 and14 patients at the 3- and 5-year follow-up, respectively.

RESULTS: After exclusion of 4 patients who discontinued the study, at the 3-year follow-up, 13 (100%) implants survived in the EMD group, and 10 of 12 (83%) in the non-EMD group. At the 5-year follow-up, 11 of 13 (85%) implants in the EMD group and 9 of 12 (75%) in the non-EMD group survived. In multivariate modelling, BL changes and EMD-treatment were positively associated with implant survival. Similarly, the same trend was seen in univariate analysis.

CONCLUSIONS: An exploratory analysis suggests that adjunctive EMD is positively associated with implant survival up to five years, but larger studies are needed. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2018. Vol. 45, no 6, p. 744-753
Keywords [en]
Bone regeneration, enamel matrix derivative, long-term outcome, peri-implantitis, surgical treatment
National Category
Dentistry
Identifiers
URN: urn:nbn:se:oru:diva-66455DOI: 10.1111/jcpe.12894ISI: 000434128500011PubMedID: 29574866Scopus ID: 2-s2.0-85045944566OAI: oai:DiVA.org:oru-66455DiVA, id: diva2:1198253
Note

Funding Agencies:

Public Dental Health County Council of Gävleborg, Sweden  

Center for Clinical Research and Development, Uppsala University/Region Gävleborg, Sweden  

Faculty of Medicine, Umeå University  

Swedish Dental Society, Sweden  

County Council of Västerbotten 

Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2018-09-12Bibliographically approved

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