oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Influence of the subtype on local recurrence risk with or without radiotherapy in a randomized trial
Örebro University, School of Medical Sciences. Department of Surgery.
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Uppsala University, Uppsala, Sweden; King’s College, London, United Kingdom.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway.
Show others and affiliations
(English)Manuscript (preprint) (Other academic)
National Category
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-66947OAI: oai:DiVA.org:oru-66947DiVA, id: diva2:1205868
Available from: 2018-05-15 Created: 2018-05-15 Last updated: 2018-05-18Bibliographically approved
In thesis
1. Adjuvant treatments to prevent local reurrence after breast-conserving surgery for early breast cancer: radiation, endocrine- or brachytherapy
Open this publication in new window or tab >>Adjuvant treatments to prevent local reurrence after breast-conserving surgery for early breast cancer: radiation, endocrine- or brachytherapy
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Radiotherapy after breast-conserving surgery due to breast cancer is an established treatment, known to reduce the incidence of recurrence and even death from the disease. However some women are over-treated with sometimes serious adverse effects. De-escalating the treatment and find alternative adjuvant methods are becoming an important issue. In study I, we present the outcomes from a long-term follow-up trial randomising 381 women with breast cancer to surgery alone or to surgery with the addition of radiotherapy. The incidence of any first breast cancer event was significantly higher without radiotherapy but the protecting effect lasted for only the first five years. In study II, we collected the tissue samples from the tumours in study I to construct tissue micro-arrays. Immuno-histochemical analyses were performed and the tumours were classified into the intrinsic subtypes. The luminal B/HER2 negative subtype was found to be prognostic for ipsilateral breast cancer recurrence (IBTR). The intrinsic subtypes did not interact with radiotherapy. Study III was a multicentre prospective cohort study where the 601 study participants with early breast cancer were treated with surgery and endocrine therapy alone without postoperative radiotherapy. The cumulative incidence of IBTR after five years was low -1.2% and only one woman died of breast cancer. In study IV we evaluated the feasibility and treatment complications when introducing a new method for intraoperative brachytherapy (IOBT) using HDR equipment. We designed a pilot study including fifty women where half of them were treated during primary surgery and the others during a second procedure. The treatment was well tolerated and no logistic problems were reported. No acute adverse effects from IOBT were seen.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2018. p. 65
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 181
Keywords
Breast-conserving surgery, radiotherapy, endocrine therapy, intraoperative brachytherapy
National Category
Surgery
Identifiers
urn:nbn:se:oru:diva-66057 (URN)978-91-7529-205-2 (ISBN)
Public defence
2018-06-08, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2018-03-26 Created: 2018-03-26 Last updated: 2018-05-16Bibliographically approved

Open Access in DiVA

No full text in DiVA

Authority records BETA

Wickberg, Åsa

Search in DiVA

By author/editor
Wickberg, Åsa
By organisation
School of Medical Sciences
Surgery

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 51 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf