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Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Örebro University, School of Medical Sciences. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.ORCID iD: 0000-0002-2856-9165
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2018 (English)In: Methods, ISSN 1046-2023, E-ISSN 1095-9130, Vol. 149, p. 3-12Article in journal (Refereed) Published
Abstract [en]

It is well established that gut microbes and their metabolic products regulate host metabolism. The interactions between the host and its gut microbiota are highly dynamic and complex. In this review we present and discuss the metabolomic strategies to study the gut microbial ecosystem. We highlight the metabolic profiling approaches to study faecal samples aimed at deciphering the metabolic product derived from gut microbiota. We also discuss how metabolomics data can be integrated with metagenomics data derived from gut microbiota and how such approaches may lead to better understanding of the microbial functions. Finally, the emerging approaches of genome-scale metabolic modelling to study microbial co-metabolism and host-microbe interactions are highlighted.

Place, publisher, year, edition, pages
Academic Press, 2018. Vol. 149, p. 3-12
Keywords [en]
Faecal metabolites, Genome-scale metabolic models, Gut microbiota, Metabolomics, Microbiome
National Category
Microbiology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-66868DOI: 10.1016/j.ymeth.2018.04.029ISI: 000448632500002PubMedID: 29715508OAI: oai:DiVA.org:oru-66868DiVA, id: diva2:1209060
Note

Funding Agencies:

Juvenile Diabetes Research Foundation  2-SRA-2014-159-Q-R 

Academy of Finland  292568 

Available from: 2018-05-21 Created: 2018-05-21 Last updated: 2018-11-13Bibliographically approved

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Oresic, Matej

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