oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study.: A longitudinal study
Örebro University, School of Science and Technology. Department of Medical Sciences and Science for Life Laboratory, Molecular Epidemiology Unit, Uppsala University, Uppsala, Sweden. (MTM Research Centre, School of Science and Technology)ORCID iD: 0000-0001-5752-4196
Örebro University, School of Science and Technology. (MTM Research Centre)
Örebro University, School of Science and Technology. (MTM Research Centre)
Department of Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Show others and affiliations
2018 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 117, p. 196-203Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: While it is known that perfluoroalkyl substances (PFASs) induce liver toxicity in experimental studies, the evidence of an association in humans is inconsistent.

OBJECTIVE: The main aim of the present study was to examine the association of PFAS concentrations and markers of liver function using panel data.

METHODS: We investigated 1002 individuals from Sweden (50% women) at ages 70, 75 and 80 in 2001-2014. Eight PFASs were measured in plasma using isotope dilution ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). Bilirubin and hepatic enzymes alanine aminotransferase (ALT), alkaline phosphatase (ALP), and γ-glutamyltransferase (GGT) were determined in serum using an immunoassay methodology. Mixed-effects linear regression models were used to examine the relationship between the changes in markers of liver function and changes in PFAS levels.

RESULTS:  = 0.11, 95% CI 0.06-0.15.

CONCLUSION: Our longitudinal assessment established associations between changes in markers of liver function and changes in plasma PFAS concentrations. These findings suggest a relationship between low-dose background PFAS exposure and altered liver function in the general population.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 117, p. 196-203
Keyword [en]
ALT, Bilirubin, Epidemiology, Liver function markers, PFAS, PFNA
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-67003DOI: 10.1016/j.envint.2018.04.052PubMedID: 29754000Scopus ID: 2-s2.0-85046747241OAI: oai:DiVA.org:oru-67003DiVA, id: diva2:1209747
Available from: 2018-05-24 Created: 2018-05-24 Last updated: 2018-05-24Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Salihovic, SamiraStubleski, JordanKärrman, Anna

Search in DiVA

By author/editor
Salihovic, SamiraStubleski, JordanKärrman, Anna
By organisation
School of Science and Technology
In the same journal
Environment International
Occupational Health and Environmental Health

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 7 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf