Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple SugarsSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Nutriomics Team, Institute of Cardiometabolism and Nutrition, Sorbonne Universités INSERM, UMRS 1166, Paris, France.
Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy.
Immunobiology Research Program, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
Helsinki Medical Imaging Centre, Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Helsinki Medical Imaging Centre, Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Immunobiology Research Program, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
Lund University, Malmö, Sweden.
Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy.
Nutriomics Team, Institute of Cardiometabolism and Nutrition, Sorbonne Universités INSERM, UMRS 1166, Paris, France; Nutrition Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.
Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
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2018 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 41, no 8, p. 1732-1739Article in journal (Refereed) Published
Abstract [en]
OBJECTIVE: Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG.
RESEARCH DESIGN AND METHODS: O) basally and during euglycemic hyperinsulinemia, insulin resistance, endotoxemia, plasma ceramides, and adipose tissue gene expression at 0 and 3 weeks.
RESULTS: < 0.05). CARB increased IHTG (+33%) by stimulating DNL (+98%). SAT significantly increased while UNSAT decreased lipolysis. SAT induced insulin resistance and endotoxemia and significantly increased multiple plasma ceramides. The diets had distinct effects on adipose tissue gene expression.
CONCLUSIONS: Macronutrient composition of excess energy influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT decreases lipolysis. SAT induced greatest increase in IHTG, insulin resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial in reducing IHTG and the associated risk of diabetes.
Place, publisher, year, edition, pages
American Diabetes Association , 2018. Vol. 41, no 8, p. 1732-1739
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-67136DOI: 10.2337/dc18-0071ISI: 000439288600025PubMedID: 29844096OAI: oai:DiVA.org:oru-67136DiVA, id: diva2:1213236
Funder
Novo Nordisk
Note
Funding Agencies:
Suomen Laaketieteen Saatio
Yrjo Jahnssonin Saatio
Emil Aaltosen Saatio
Diabetes Research Foundation
Helsingin Yliopisto
Elucidating Pathways of Steatohepatitis consortium - Horizon 2020 Framework Program of the European Union EPoS 634413
Ministero dell'Istruzione, dell'Universita e della Ricerca
Consiglio Nazionale delle Ricerche
PIA-F-Crin Force program
British Heart Foundation Intermediate Fellowship in Basic Science FS/11/18/28633
Suomen Akatemia
Sigrid Juselius Foundation
Evo
EU/EFPIA Innovative Medicines Initiative Joint Undertaking EMIF 115372
2018-06-042018-06-042019-03-04Bibliographically approved