oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
High cyclin A expression, but not Ki67, is associated with early recurrence in desmoid tumors
Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Department of Pathology, HUSLAB and University of Helsinki, Helsinki, Finland.
Department of Pathology, HUSLAB and University of Helsinki, Helsinki, Finland.
Show others and affiliations
2018 (English)In: Journal of Surgical Oncology, ISSN 0022-4790, E-ISSN 1096-9098Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND AND OBJECTIVES: Desmoid tumors are soft-tissue tumors originating from myofibroblasts with a tendency to recur after surgery. High expression of proliferation markers is associated with shortened progression-free and/or overall survival in many neoplasms, including soft-tissue sarcomas. We investigated the prognostic role of cyclin A and Ki67 in desmoid tumors by immunohistochemistry.

METHODS: The study included 76 patients with desmoid tumor operated at Helsinki University Hospital between 1987 and 2011. A tissue micro array (TMA) was constructed and the TMA sections were immunostained with cyclin A and Ki67 antibodies. A computer-assisted image analysis was performed.

RESULTS: Cyclin A expression was evaluable in 74 and Ki67 in 70 patients. Cyclin A immunopositivity varied from 0% to 9.9%, with a mean of 1.9%. Cyclin A expression correlated significantly with Ki67. Cyclin A expression was associated with recurrence-free survival (HR 1.9, 95% CI = 1.1-3.2, P = .02), as were positive margin (HR 6.0, 95% CI = 1.6-22.5, P = .008) and extremity location (HR 5.3, 95% CI = 1.7-16.8, P = 0.005). Ki67 immunopositivity varied from 0.33% to 13.8%, with a mean of 4.6%, but had no significant prognostic impact (HR 1.1, P = .2).

CONCLUSIONS: Our study indicates that cyclin A may be a new prognostic biomarker in surgically treated desmoid tumors.

Place, publisher, year, edition, pages
Wiley-Interscience Publishers , 2018.
Keywords [en]
Aggressive fibromatosis, biomarkers, cyclins, immunohistochemistry, prognostic factors
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-67219DOI: 10.1002/jso.25121PubMedID: 29878366OAI: oai:DiVA.org:oru-67219DiVA, id: diva2:1216394
Available from: 2018-06-11 Created: 2018-06-11 Last updated: 2018-06-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Karlsson, Christina

Search in DiVA

By author/editor
Karlsson, Christina
By organisation
School of Health Sciences
In the same journal
Journal of Surgical Oncology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf