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Contact allergy to oxidized geraniol among Swedish dermatitis patients: A multicentre study by the Swedish Contact Dermatitis Research Group
Department of Dermatology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
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2018 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 79, no 4, p. 232-238Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%.

AIM: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting.

METHODS: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet. and oxidized geraniol 6% and 11% pet.

RESULTS: Pure geraniol 6% pet., oxidized geraniol 6% pet. and oxidized geraniol 11% pet. gave 1%, 3% and 8% positive patch test reactions and 0.7%, 3% and 5% doubtful reactions, respectively. Approximately 50% of the patients with doubtful reactions to oxidized geraniol 6% pet. had positive reactions to oxidized geraniol 11% pet.

CONCLUSIONS: Oxidized geraniol 11% pet. provides better detection than oxidized geraniol 6% pet. As most patients reacted only to oxidized geraniol, it is important to explore further whether oxidized geraniol should be included in a baseline patch test series.

Place, publisher, year, edition, pages
Blackwell Publishing, 2018. Vol. 79, no 4, p. 232-238
Keywords [en]
allergic contact dermatitis, autoxidation, fragrance contact allergy, fragrance mix I, geraniol, patch testing, terpenes
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-67512DOI: 10.1111/cod.13047ISI: 000443805100006PubMedID: 29926925Scopus ID: 2-s2.0-85052815523OAI: oai:DiVA.org:oru-67512DiVA, id: diva2:1224036
Note

Funding Agency:

Edvard Welanders Stiftelse 

Available from: 2018-06-26 Created: 2018-06-26 Last updated: 2018-09-25Bibliographically approved

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Lindberg, Magnus

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