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Impact of Heart Rate on Flow Measurements in Aortic Regurgitation
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-1346-1450
Department of Clinical Physiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences. Department of Medical Physics.ORCID iD: 0000-0002-8351-3367
Örebro University Hospital. Örebro University, School of Medical Sciences.ORCID iD: 0000-0001-8982-4572
2017 (English)In: Journal of Heart Valve Disease, ISSN 0966-8519, E-ISSN 2053-2644, Vol. 26, no 5, p. 502-508, article id 4562Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Flow measurements using cardiac magnetic resonance imaging (CMRI) enable quantification of the stroke volume, regurgitant volume (RV) and regurgitant fraction (RF) in patients with aortic regurgitation (AR). These variables are used to assess the severity of the valve disease and for the timing of surgery. The aim of the study was to investigate the impact of an increased heart rate on measurement of the RV and RF in patients with AR.

METHODS: Among 13 patients with known moderate or severe AR, regurgitant flow measurements, using phase-contrast cine magnetic resonance imaging, were obtained in the ascending aorta. Flow measurements were obtained at rest and at increased heart rates after intravenous administration of atropine.

RESULTS: The mean heart rate was 61 beats per min at rest and 91 beats per min after atropine administration. The RV and RF were 52 ml and 35% at rest, respectively, and 34 ml (p <0.001) and 30% (p = 0.065) at increased heart rate, respectively.

CONCLUSIONS: An increased heart rate leads to a decreased RV. The RF is more stable and may therefore be preferable for severity grading in AR.

Place, publisher, year, edition, pages
I C R Publishers Ltd. , 2017. Vol. 26, no 5, p. 502-508, article id 4562
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-67603PubMedID: 29762918OAI: oai:DiVA.org:oru-67603DiVA, id: diva2:1228730
Available from: 2018-06-28 Created: 2018-06-28 Last updated: 2019-03-26Bibliographically approved

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Lidén, MatsThunberg, PerRask, Peter

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