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Risk of Fractures in Youths with Celiac Disease: A Population-Based Study
Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Epidemiological Service, Health Directorate, Friuli Venezia-Giulia Region, Udine, Italy.
Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
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2018 (English)In: Journal of Pediatric Surgery Case Reports, ISSN 0022-3476, E-ISSN 2213-5766, Vol. 198, p. 117-120Article in journal (Refereed) Published
Abstract [en]

Objective: To assess the risk of any fracture requiring hospital care in a cohort of individuals with celiac disease diagnosed in childhood/adolescence compared with reference individuals matched by age and sex.

Study design: Our study cohort consisted of 213 635 people born and residing in Friuli-Venezia Giulia Region, Italy, in 1989-2011. We selected, through pathology reports, hospital discharge records, or co-payment exemptions, 1233 individuals with celiac disease (aged 0-17 years at diagnosis) and compared them with 6167 reference individuals matched by sex and year of birth. Fractures were identified through hospital discharge records. We calculated hazard ratios (HRs) for any fracture after celiac disease diagnosis (or index date for reference individuals) with Cox regression and ORs for any fracture before celiac disease diagnosis with conditional logistic regression.

Results: During the follow-up period (maximum 23 years), 22 individuals with celiac disease (9394 person-years) and 128 reference individuals (47 308 person-years) experienced a fracture. giving an overall HR of 0.87 (95% CI 0.55-1.37). The risk was not modified by sex, age at diagnosis, or calendar period of diagnosis. We obtained similar HRs when excluding fractures occurring after the age of 18 years and adjusting for maternal education or vitamin D supplementation. The odds of previous fracture also did not differ between subjects with celiac disease and reference individuals (22 and 96 cases, respectively: OR 1.15: 95% CI 0.72-1.84).

Conclusions: We did not find any evidence of an increased risk of fractures during childhood and youth among patients with celiac disease.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 198, p. 117-120
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-68142DOI: 10.1016/j.jpeds.2018.02.070ISI: 000436817000022PubMedID: 29681452Scopus ID: 2-s2.0-85045920357OAI: oai:DiVA.org:oru-68142DiVA, id: diva2:1235545
Note

Funding Agency:

University of Padua  F.S. 4.18.01.05

Available from: 2018-07-26 Created: 2018-07-26 Last updated: 2018-07-26Bibliographically approved

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Ludvigsson, Jonas F.

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