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Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 10635Article in journal (Refereed) Published
Abstract [en]

Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, article id 10635
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-68333DOI: 10.1038/s41598-018-28907-8ISI: 000438490500003PubMedID: 30006587Scopus ID: 2-s2.0-85049952074OAI: oai:DiVA.org:oru-68333DiVA, id: diva2:1236431
Note

Funding Agencies:

JDRF  4-1998-274  4-1999-731 4-2001-435 

Juvenile Diabetes Research Foundation  2-SRA-2014-159-Q-R 

Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research - SyMMyS)  250114 

Turku University Hospitals in Finland  

Special research funds for Oulu, Tampere 

Available from: 2018-08-02 Created: 2018-08-02 Last updated: 2019-03-04Bibliographically approved

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Hyötyläinen, TuuliaOresic, Matej

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Citation style
  • apa
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