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Staphylococcus epidermidis from prosthetic joint infections induces lower IL-1 release from human neutrophils than isolates from normal flora
Örebro University, School of Medical Sciences. Centre for Clinical Research, Hospital of Västmanland, Region Västmanland, Västerås,Sweden; Centre for Clinical Research, Hospital of Västmanland, Uppsala University, Västerås, Sweden. (iRiSC – Inflammatory Response and Infection Susceptibility Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden)ORCID iD: 0000-0003-2867-1044
Örebro University, School of Medical Sciences. Department of Laboratory Medicine, Clinical Microbiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden. (iRiSC – Inflammatory Response and Infection Susceptibility Centre)ORCID iD: 0000-0001-5939-2932
Department of Infectious Diseases, Department of Clinical and Experimental Medicine, Linköping University, Norrköping, Sweden.
Örebro University, School of Medical Sciences. (iRiSC – Inflammatory Response and Infection Susceptibility Centre)ORCID iD: 0000-0002-4319-7208
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2018 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 126, no 8, p. 678-684Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to test the hypothesis that Staphylococcus epidermidis isolated from prosthetic joint infections (PJIs) differs from S.epidermidis isolated from normal flora in terms of its capacity to induce activation of caspase-1 and release of IL-1 in human neutrophils. The amount of active caspase-1 was determined over 6h by detecting Ac-YVAD-AMC fluorescence in human neutrophils incubated with S.epidermidis isolates from PJIs (ST2) or normal flora. The amount of IL-1 was detected by ELISA in neutrophil supernatants after 6h of incubation. Mean IL-1 release was lower after incubation with S.epidermidis from PJIs compared to isolates from normal flora, but no statistically significant difference was found in active caspase-1. Substantial inter-individual differences in both active caspase-1 and IL-1 were noted. These results suggest that evasion of innate immune response, measured as reduced capacity to induce release of IL-1 from human neutrophils, might be involved in the predominance of ST2 in S.epidermidis PJIs, but that other microbe-related factors are probably also important.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2018. Vol. 126, no 8, p. 678-684
Keywords [en]
Staphylococcus epidermidis, prosthesis-related infections, pathology, host-pathogen interactions, immunology, caspase-1, interleukin-1beta
National Category
Immunology in the medical area Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-68468DOI: 10.1111/apm.12861ISI: 000440136000004Scopus ID: 2-s2.0-85050768159OAI: oai:DiVA.org:oru-68468DiVA, id: diva2:1239065
Available from: 2018-08-15 Created: 2018-08-15 Last updated: 2018-09-07Bibliographically approved

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Månsson, EmeliSöderquist, BoSärndahl, EvaDemirel, Isak

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Immunology in the medical areaMicrobiology in the medical area

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