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Advancing the public health applications of Chlamydia trachomatis serology
Public Health England, London, UK; University of Bristol, Bristol, UK; University College London, London, UK.
US Centers for Disease Control and Prevention, Atlanta GA, USA.
Public Health England, London, UK; London School of Hygiene & Tropical Medicine, London, UK.
World Health Organization, Geneva, Switzerland.
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2018 (English)In: Lancet. Infectious diseases (Print), ISSN 1473-3099, E-ISSN 1474-4457, Vol. 18, no 12, p. E399-E407Article, review/survey (Refereed) Published
Abstract [en]

Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the leading infectious cause of blindness worldwide. New serological assays for C trachomatis could facilitate improved understanding of C trachomatis epidemiology and prevention. C trachomatis serology offers a means of investigating the incidence of chlamydia infection and might be developed as a biomarker of scarring sequelae, such as pelvic inflammatory disease. Therefore, serological assays have potential as epidemiological tools to quantify unmet need, inform service planning, evaluate interventions including screening and treatment, and to assess new vaccine candidates. However, questions about the performance characteristics and interpretation of C trachomatis serological assays remain, which must be addressed to advance development within this field. In this Personal View, we explore the available information about C trachomatis serology and propose several priority actions. These actions involve development of target product profiles to guide assay selection and assessment across multiple applications and populations, establishment of a serum bank to facilitate assay development and evaluation, and development of technical and statistical methods for assay evaluation and analysis of serological findings. The field of C trachomatis serology will benefit from collaboration across the public health community to align technological developments with their potential applications.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 18, no 12, p. E399-E407
National Category
Infectious Medicine Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-68365DOI: 10.1016/S1473-3099(18)30159-2ISI: 000450899900004PubMedID: 29983342OAI: oai:DiVA.org:oru-68365DiVA, id: diva2:1239320
Note

Funding Agencies:

Public Health England  

National Institute of Health Research Health Protection Research Unit (NIHR HPRU) in Evaluation of Interventions at the University of Bristol  

NIHR HPRU in Blood Borne and Sexually Transmitted Infections at University College London 

Available from: 2018-08-16 Created: 2018-08-16 Last updated: 2018-12-05Bibliographically approved

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