oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The effect of continuous levodopa treatment during the afternoon hours
Department of Micro‐data analysis, Dalarna University, Falun, Sweden.
Örebro University, Örebro University School of Business.ORCID iD: 0000-0002-2372-4226
Department of Micro‐data analysis, Dalarna University, Falun, Sweden.
Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
2019 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 139, no 1, p. 70-75Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this retrospective study was to investigate if patients with PD, who are treated with levodopa‐carbidopa intestinal gel (LCIG), clinically worsen during the afternoon hours and if so, to evaluate whether this occurs in all LCIG‐treated patients or in a sub‐group of patients.

Methods: Three published studies were identified and included in the analysis. All studies provided individual response data assessed on the treatment response scale (TRS) and patients were treated with continuous LCIG. Ninety‐eight patients from the three studies fulfilled the criteria. T‐tests were performed to find differences on the TRS values between the morning and the afternoon hours, linear mixed effect models were fitted on the afternoon hours’ evaluations to find trends of wearing‐off, and patients were classified into three TRS categories (meaningful increase in TRS, meaningful decrease in TRS, non ‐meaningful increase or decrease).

Results: In all three studies significant statistical differences were found between the morning TRS values and the afternoon TRS values (p‐value <= 0.001 in all studies). The linear mixed effect models had significant negative coefficients for time in two studies, and 48 out of 98 patients (49%) showed a meaningful decrease of TRS during the afternoon hours.

Conclusion: The results from all studies were consistent, both in the proportion of patients in the three groups and the value of TRS decrease in the afternoon hours. Based on these findings there seems to be a group of patients with predictable “off” behavior in the later parts of the day.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 139, no 1, p. 70-75
Keywords [en]
diurnal motor fluctuation, infusion pumps, levodopa, Parkinson disease
National Category
Neurology Computer and Information Sciences
Research subject
Informatics
Identifiers
URN: urn:nbn:se:oru:diva-68788DOI: 10.1111/ane.13020ISI: 000452067700007PubMedID: 30180267Scopus ID: 2-s2.0-85053714059OAI: oai:DiVA.org:oru-68788DiVA, id: diva2:1246260
Note

Funding Agencies:

Dalarna University  

Uppsala University  

Örebro University 

Available from: 2018-09-07 Created: 2018-09-07 Last updated: 2019-01-07Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Memedi, Mevludin

Search in DiVA

By author/editor
Memedi, Mevludin
By organisation
Örebro University School of Business
In the same journal
Acta Neurologica Scandinavica
NeurologyComputer and Information Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 120 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf