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Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms
Örebro University, School of Medical Sciences. (Nutrition-Gut-Brain Interactions Research Centre; Nutrition and Physical Activity Research Centre)
Örebro University, School of Medical Sciences. (Nutrition-Gut-Brain Interactions Research Centre)
Örebro University, School of Medical Sciences. (Nutrition-Gut-Brain Interactions Research Centre)
Örebro University, School of Medical Sciences. (Nutrition-Gut-Brain Interactions Research Centre)ORCID iD: 0000-0002-0362-0008
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, no 1, article id 13404Article in journal (Refereed) Published
Abstract [en]

Gastrointestinal problems are common in elderly and often associated with psychological distress and increased levels of corticotrophin-releasing hormone, a hormone known to cause mast cell (MC) degranulation and perturbed intestinal barrier function. We investigated if dietary fibres (non-digestible polysaccharides [NPS]) could attenuate MC-induced colonic hyperpermeability in elderly with gastrointestinal (GI) symptoms. Colonic biopsies from elderly with diarrhoea and/or constipation (n = 18) and healthy controls (n = 19) were mounted in Ussing chambers and pre-stimulated with a yeast-derived beta (β)-glucan (0.5 mg/ml) or wheat-derived arabinoxylan (0.1 mg/ml) before the addition of the MC-degranulator Compound (C) 48/80 (10 ng/ml). Permeability markers were compared pre and post exposure to C48/80 in both groups and revealed higher baseline permeability in elderly with GI symptoms. β-glucan significantly attenuated C48/80-induced hyperpermeability in elderly with GI symptoms but not in healthy controls. Arabinoxylan reduced MC-induced paracellular and transcellular hyperpermeability across the colonic mucosa of healthy controls, but did only attenuate transcellular permeability in elderly with GI symptoms. Our novel findings indicate that NPS affect the intestinal barrier differently depending on the presence of GI symptoms and could be important in the treatment of moderate constipation and/or diarrhoea in elderly.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, no 1, article id 13404
National Category
Gastroenterology and Hepatology Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-68799DOI: 10.1038/s41598-018-31492-5ISI: 000444022800008PubMedID: 30194322Scopus ID: 2-s2.0-85053008629OAI: oai:DiVA.org:oru-68799DiVA, id: diva2:1246701
Available from: 2018-09-10 Created: 2018-09-10 Last updated: 2018-09-28Bibliographically approved

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Ganda Mall, John PeterLöfvendahl, LisaLindqvist, Carl MårtenBrummer, Robert JanSchoultz, Ida

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