To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Opium use during pregnancy and infant size at birth: a cohort study
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, Sweden; Department of Obstetrics & Gynecology, McMaster University, Hamilton, ON, Canada.
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, Sweden.
Örebro University, School of Medical Sciences. Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, Sweden; Department of Epidemiology and Public Health, University College London, London, UK. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0001-6328-5494
Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Show others and affiliations
2018 (English)In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 18, no 1, article id 358Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The reported positive association between opiatic drug use during pregnancy and adverse pregnancy outcomes might be confounded by other factors related to high-risk behaviors, including the use of other harmful substances. In rural areas of Iran, opium use during pregnancy is relatively common among women who otherwise do not have a hazardous lifestyle, which reduces the risk of residual confounding and increasing the possibility to identify its effects. We aimed to examine the association of antenatal exposure to opium with risks of small for gestational age, short birth length, and small head circumference at birth.

METHOD: In this cohort study in the rural area of the Golestan province, Iran, we randomly selected 920 women who were exposed to opium during pregnancy and 920 unexposed women during 2008-2010. Log-binomial regression was used to estimate risk ratios (RR) and 95% confidence intervals (CI) for the associations between prenatal exposure to opium and risks of small for gestational age, short birth length, and small head circumference at birth.

RESULTS: Compared with non-use of opium and tobacco during pregnancy, using opium only and dual use of opium and tobacco were associated with increased risks of small for gestational age at births (RR = 1.71; 95% CI 1.34-2.18 and RR = 1.62; 95% CI 1.13-2.30, respectively). Compared with non-use of opium and tobacco, exposure to only opium or dual use of opium and tobacco were also associated with more than doubled increased risks of short birth length, and small head circumference in term infants.

CONCLUSION: Maternal opium use during pregnancy is associated with increased risks of giving birth to a small for gestational age infant, as well as a term infant with short birth length or small head circumference.

Place, publisher, year, edition, pages
BioMed Central, 2018. Vol. 18, no 1, article id 358
Keywords [en]
Birth size, Iran, Opium, Pregnancy, Small for gestational age
National Category
Obstetrics, Gynecology and Reproductive Medicine Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-69213DOI: 10.1186/s12884-018-1994-8ISI: 000446222200001PubMedID: 30269686Scopus ID: 2-s2.0-85054477744OAI: oai:DiVA.org:oru-69213DiVA, id: diva2:1253188
Funder
The Karolinska Institutet's Research FoundationAvailable from: 2018-10-04 Created: 2018-10-04 Last updated: 2018-10-16Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Montgomery, Scott

Search in DiVA

By author/editor
Montgomery, Scott
By organisation
School of Medical Sciences
In the same journal
BMC Pregnancy and Childbirth
Obstetrics, Gynecology and Reproductive MedicineOccupational Health and Environmental Health

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 294 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf