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Use of the Biodegradable Polymer Chitosan as a Vehicle for Applying Drugs to the Inner Ear
Center for Hearing and Communication Research, Karolinska Institute, Stockholm, Sweden; Department of Otolaryngology, Karolinska University Hospital, Stockholm, Sweden.
The Norwegian Biopolymer Laboratory (NOBIPOL), Deptartment of Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.
Center for Hearing and Communication Research, Karolinska Institute, Stockholm, Sweden; Department of Otolaryngology, Karolinska University Hospital, Stockholm, Sweden.
2010 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Development of efficient local delivery systems for the auditory organ has an important role in clinical practice for the management of inner ear disorders using pharmacological means. Chitosan, a biodegradable polymer, is a good drug carrier with bioadhesive properties. The aim of this study was to investigate the feasibility of using chitosan to deliver drugs to the inner ear across the round window membrane (RWM). Three structurally different chitosans loaded with a tracer drug, neomycin, were injected into the middle ear cavity of albino guinea pigs (n=35). After 7 days the effect of chitosans and neomycin was compared among the treatment groups. The hearing organ was analysed for hair cell loss and the RWM evaluated in term of thickness. All tested chitosan formulations successfully released the loaded neomycin which then diffused across the RWM, and exerted ototoxic effect on the cochlear hair cells in a degree depending on the concentrations used. Chitosans per se had no noxious effect on the cochlear hair cells. It is concluded that the chitosans, and especially glycosylated derivative, are safe and effective carriers for inner ear therapy.

Place, publisher, year, edition, pages
2010.
National Category
Otorhinolaryngology Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:oru:diva-69322OAI: oai:DiVA.org:oru-69322DiVA, id: diva2:1253744
Conference
33rd Annual MidWinter Research Meeting of the Association for Research in Otolaryngology, Anaheim, California, USA, February 6-10, 2010
Available from: 2018-10-05 Created: 2018-10-05 Last updated: 2019-07-10Bibliographically approved

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Saber, Amanj

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf