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PRO - To Prime Or Not to Prime?
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-9986-8138
2018 (English)In: Hormone Research in Paediatrics, ISSN 1663-2818, E-ISSN 1663-2826, Vol. 90, no Suppl.1, p. 18-19Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Recent progress in the understanding of growth disorders has further emphasized that growth hormone deficiency is only one of many causes for growth failure and that growth hormone deficiency (GHD) is over-diagnosed in children with short stature. Over-diagnosis of GHD is problematic as it incorrectly labels children with pituitary disease, leads to overtreatment and misin-formation of patients and families, and may sometimes prevent doctors from making the correct diagnosis. Methods that can im-prove the specificity of GH testing are therefore urgently needed. Estrogen priming of prepubertal children is safe and inexpensive. Available data suggest that it increases specificity and therefore improves testing performance. In this presentation, I will discuss estrogen priming and argue that it should be used if the purpose of testing is to accurately determine whether the child is GH deficient.

Place, publisher, year, edition, pages
S. Karger, 2018. Vol. 90, no Suppl.1, p. 18-19
National Category
Endocrinology and Diabetes Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-69557ISI: 000445204100044OAI: oai:DiVA.org:oru-69557DiVA, id: diva2:1256562
Conference
57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2018), Athens, Greece, September 27-29, 2018
Available from: 2018-10-17 Created: 2018-10-17 Last updated: 2018-10-17Bibliographically approved

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Nilsson, Ola

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