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HPV16 viral characteristics in primary, recurrent and metastatic vulvar carcinoma
Örebro University, School of Health Sciences. Department of Laboratory Medicine.ORCID iD: 0000-0001-9992-266x
Örebro University, School of Medical Sciences. Department of Laboratory Medicine.
Örebro University, School of Health Sciences. Department of Oncology.ORCID iD: 0000-0002-5063-631X
Örebro University, School of Medical Sciences. Department of Laboratory Medicine.ORCID iD: 0000-0003-2317-5738
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2018 (English)In: Papillomavirus research, ISSN 2405-8521, Vol. 6, p. 63-69Article in journal (Refereed) Published
Abstract [en]

Vulvar carcinoma is the fourth most common gynecological malignancy. Two separate carcinogenic pathways are suggested, where one is associated with the human papillomavirus (HPV) and HPV16 the most common genotype.

The aim of this study was to evaluate HPV-markers in a set of primary tumors, metastases and recurrent lesions of vulvar squamous cell carcinomas (VSCC). Ten HPV16-positive VSCC with metastatic regional lymph nodes, distant lymphoid/hematogenous metastases or local recurrent lesions were investigated for HPV genotype, HPV16 variant, HPV16 viral load, HPV16 integration and HPV16 E2BS3 and 4 methylation.

In all 10 analyzed case series, the same HPV genotype (HPV16), HPV16 variant and level of viral load were detected in all lesions within a patient case. Primary tumors with a high E2/E6 ratio were found to have fewer vulvar recurrences and/or metastases after diagnosis and treatment. Also, a significantly lower viral load was evident in regional lymph nodes compared to primary tumors.

The data presented strengthens the evidence for a clonal HPV-induced pathway for vulvar carcinoma.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 6, p. 63-69
Keywords [en]
Vulvar carcinoma, human papillomavirus, integration, metastases, recurrences, viral load
National Category
Cancer and Oncology Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-69992DOI: 10.1016/j.pvr.2018.10.008ISI: 000452069800012PubMedID: 30391517Scopus ID: 2-s2.0-85056569332OAI: oai:DiVA.org:oru-69992DiVA, id: diva2:1261535
Note

Funding Agency:

Örebro County Council Research Committee

Available from: 2018-11-07 Created: 2018-11-07 Last updated: 2018-12-17Bibliographically approved

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Lillsunde Larsson, GabriellaKaliff, MalinSorbe, BengtHelenius, GiselaKarlsson, Mats G.

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Lillsunde Larsson, GabriellaKaliff, MalinSorbe, BengtHelenius, GiselaKarlsson, Mats G.
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School of Health SciencesSchool of Medical Sciences
Cancer and OncologyDermatology and Venereal Diseases

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