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A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
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2018 (English)In: Scientific Data, E-ISSN 2052-4463, Vol. 5, article id 180250Article in journal (Refereed) Published
Abstract [en]

Early prediction and prevention of type 1 diabetes (T1D) are currently unmet medical needs. Previous metabolomics studies suggest that children who develop T1D are characterised by a distinct metabolic profile already detectable during infancy, prior to the onset of islet autoimmunity. However, the specificity of persistent metabolic disturbances in relation T1D development has not yet been established. Here, we report a longitudinal plasma lipidomics dataset from (1) 40 children who progressed to T1D during follow-up, (2) 40 children who developed single islet autoantibody but did not develop T1D and (3) 40 matched controls (6 time points: 3, 6, 12, 18, 24 and 36 months of age). This dataset may help other researchers in studying age-dependent progression of islet autoimmunity and T1D as well as of the age-dependence of lipidomic profiles in general. Alternatively, this dataset could more broadly used for the development of methods for the analysis of longitudinal multivariate data.

Place, publisher, year, edition, pages
Springer Nature , 2018. Vol. 5, article id 180250
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-70175DOI: 10.1038/sdata.2018.250ISI: 000449924000001PubMedID: 30422126Scopus ID: 2-s2.0-85056307525OAI: oai:DiVA.org:oru-70175DiVA, id: diva2:1263499
Note

Funding agencies:

JDRF (grants 4-1998-274, 4-1999-731 4-2001-435)

Oulu, Tampere and Turku University Hospitals

Juvenile Diabetes Research Foundation (2-SRA-2014-159-Q-R)

Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research – SyMMyS, Decision No. 250114)

Available from: 2018-11-15 Created: 2018-11-15 Last updated: 2019-03-04Bibliographically approved

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Hyötyläinen, TuuliaOresic, Matej

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CiteExportLink to record
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Citation style
  • apa
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