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Current EU research activities on combined exposure to multiple chemicals
European Commission, Directorate General Joint Research Centre, Directorate F – Health, Consumers and Reference Materials, Ispra, Italy.ORCID iD: 0000-0003-1082-8007
INSERM UMR-S 1124, Université Paris Descartes, Paris, France.
Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany.
European Commission, Directorate General Joint Research Centre, Directorate B – Growth and Innovation, Ispra, Italy.
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2018 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 120, p. 544-562Article, review/survey (Refereed) Published
Abstract [en]

Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 120, p. 544-562
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-70210DOI: 10.1016/j.envint.2018.07.037ISI: 000448688500056PubMedID: 30170309OAI: oai:DiVA.org:oru-70210DiVA, id: diva2:1264635
Funder
Swedish Research Council
Note

Funding Agencies:

European Union's Seventh Framework Programme for research, technological development and demonstration  603437 

European Union's Horizon 2020 research and innovation programme  634880  633172  733032  681002 

Strategic Programme RIVM 

Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-20Bibliographically approved

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Bergman, Åke

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