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The influence of prostatic Cutibacterium acnes infection on serum levels of IL6 and CXCL8 in prostate cancer patients
Örebro University, School of Medical Sciences. Department of Urology.
Örebro University, School of Medical Sciences. Department of Urology.ORCID iD: 0000-0001-5533-7899
Örebro University, School of Medical Sciences.ORCID iD: 0000-0001-5939-2932
Örebro University, School of Medical Sciences. Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0002-3649-2639
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2018 (English)In: Infectious Agents and Cancer, ISSN 1750-9378, E-ISSN 1750-9378, Vol. 13, article id 34Article in journal (Refereed) Published
Abstract [en]

Background: Chronic prostatic inflammation, caused by Cutibacterium acnes (C. acnes), has been proposed to influence the risk of prostate cancer development. In vitro studies have demonstrated the capacity of C. acnes to induce secretion of Interleukin 6 (IL6) and C-X-C motif chemokine ligand 8 (CXCL8) by prostate epithelial cells. Both these inflammatory mediators have been implicated in prostate cancer pathophysiology. In this cohort study, we aimed to investigate the influence of prostatic C. acnes on serum levels of IL6 and CXCL8.

Methods: We recruited 99 prostate cancer patients who underwent radical prostatectomy at orebro University Hospital. The cultivation of pre-operatively obtained prostate biopsies identified C. acnes in 60 of the 99 patients. Levels of IL6 and CXCL8 in pre-operative serum samples were analyzed using ELISA, and concentrations were compared between prostate cancer patients with and without prostatic C. acnes infection using standard statistical methods.

Results: No statistical differences were observed in serum levels of IL6 and CXCL8 between subjects with and without prostatic C. acnes infection.

Conclusions: Our results indicate that prostatic C. acnes infection may give rise to low-grade inflammation with little effect on systemic levels of IL6 and CXCL8.

Place, publisher, year, edition, pages
BioMed Central, 2018. Vol. 13, article id 34
Keywords [en]
Prostate cancer, Inflammation, Cutibacterium acnes, IL6, CXCL8, Cytokines
National Category
Cancer and Oncology Immunology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-70366DOI: 10.1186/s13027-018-0204-7ISI: 000450287500001PubMedID: 30473726Scopus ID: 2-s2.0-85056906445OAI: oai:DiVA.org:oru-70366DiVA, id: diva2:1266751
Note

Funding Agency:

Foundation Lions Cancerforskningsfond vid Akademiska sjukhuset i Uppsala 

Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2019-04-08Bibliographically approved
In thesis
1. Inflammation and prostate carcinogenesis: influence of immune characteristics and early-adulthood exposure to inflammatory conditions on prostate cancer risk
Open this publication in new window or tab >>Inflammation and prostate carcinogenesis: influence of immune characteristics and early-adulthood exposure to inflammatory conditions on prostate cancer risk
2019 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Chronic inflammation has been implicated in the development of several types of cancer, and evidence from observational and animal studies suggests that it may play a role also in prostate carcinogenesis. Recent observations have brought Cutibacterium acnes (C. acnes) forward as a possible causative agent in pro-oncogenic prostatic inflammation. However, evidence also suggest that underlying immune characteristics contribute to prostate cancer risk. The overall aim of this thesis was to explore potential mechanisms underlying the proposed link between inflammation and prostate cancer, by evaluating associations between inflammatory conditions during early adulthood, circulating inflammation markers, and prostate cancer. Due to the suggested role of C. acnes in both diseases, we aimed to investigate whether acne vulgaris is a determinant of prostate cancer. Using prospectively collected data from Swedish national registers, we observed that presence of acne during early adulthood conferred an increased risk of prostate cancer later in life. Similarly, we found that appendicitis before late adolescence – a proposed marker of individual immune characteristics – to be positively associated with subsequent prostate cancer. We further evaluated whether prostatic C. acnes infection is linked with elevated systemic levels of IL6 and CXCL8, two inflammation markers previously associated with prostate cancer. No association was observed, however, potentially explained by the subclinical low-grade infection typically caused by C. acnes. Finally, we evaluated 52 circulating inflammation markers as determinants for prostate cancer in a population-based case-control study. In this hypothesis-generating study, we identified CX3CL1, CCL21, PDGF-BB, CCL11 and IL10 as candidate markers for evaluation in prospective studies. If confirmed, these markers may hint at targetable molecular pathways involved in prostate carcinogenesis.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2019. p. 100
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 191
Keywords
Prostate cancer, inflammation, Cutibacterium acnes, acne, appendicitis, cytokines, circulating, inflammation marker, IL6, CXCL8
National Category
Surgery
Identifiers
urn:nbn:se:oru:diva-72812 (URN)978-91-7529-280-9 (ISBN)
Public defence
2019-05-10, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 12:30 (Swedish)
Opponent
Supervisors
Available from: 2019-02-27 Created: 2019-02-27 Last updated: 2019-04-10Bibliographically approved

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Ugge, HenrikCarlsson, JessicaSöderquist, BoFall, KatjaAndrén, OveDavidsson, Sabina

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