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Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease
Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden; Infectious Diseases, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden; Infectious Diseases, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
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2018 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 9, article id 2746Article in journal (Refereed) Published
Abstract [en]

Pneumococcal polysaccharide vaccines may elicit a hyporesponse under certain conditions. There is limited knowledge, however, on the type of specific antibody response in individuals with invasive pneumococcal disease (IPD). The aim of this study was to investigate the functional antibody response in patients with IPD caused by different serotypes. Pre-immune and convalescent sera from 40 patients (age 14-91 years) with IPD caused by serotypes with low (serotype 3, 19F, and 23F) and high (1, 4, 7F, and 14) invasive potential were investigated. For each patient, the homologous serotype-specific antibody concentration was determined. The functionality of induced antibodies post-IPD was evaluated in an opsonophagocytic assay (OPA). Undetectable or decreased pneumococcal killing in OPA following IPD, i.e., a nonfunctional antibody response, was observed in 24 of 40 patients (60%). Patients with nonfunctional antibody responses had lower serotype specific IgG antibody ratios post-IPD than patients with increased OPA titres. A nonfunctional antibody response was associated with low invasive serotypes (3, 19F, and 23F, p = 0.015). In conclusion, a nonfunctional antibody response may follow IPD, and was in our cohort associated to serotypes with low invasive potential. These findings need to be confirmed in a larger material.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018. Vol. 9, article id 2746
Keywords [en]
antibody, opsonization, sepsis, serotype, Streptococcus pneumoniae
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-70365DOI: 10.3389/fmicb.2018.02746ISI: 000450175100001Scopus ID: 2-s2.0-85056728506OAI: oai:DiVA.org:oru-70365DiVA, id: diva2:1266755
Funder
Swedish Heart Lung Foundation, 20150697
Note

Funding Agencies:

Anna and Edwin Berger Foundation  

Swedish Medical Research Council  K2015-57X-03163-43-4 

Cancer Foundation at the University Hospital in Malmö  

Royal Physiographical Society  

Skåne County Council's Research and Development Foundation

Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2019-04-24Bibliographically approved

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Athlin, Simon

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