oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Alzheimer’s Disease and Occupational Exposures: A Systematic Literature Review and Meta-Analyses
Örebro University, School of Medical Sciences. Department of Occupational and Environmental Medicine, Örebro University, Sweden.ORCID iD: 0000-0002-4192-8273
Örebro University, Örebro University School of Business. Institute of Environmental Medicine, Karolinska Institute, Solna, Sweden.
2018 (English)In: Alzheimer's Disease & Treatment, Open Access ebooks , 2018Chapter in book (Refereed)
Abstract [en]

Six systematic literature reviews together with meta-analyses have been published on the associations between Alzheimer’s disease and occupational risk factors. Our meta-analyses were based only on studies fulfilling good standards of scientific quality. We scrutinized the 54 relevant original publications found using a checklist proposed by the MOOSE-group together with a new elaborated protocol. Thus our results are not hampered by bias from studies of lower scientific quality. Thirty publications fulfilled good scientific standards and were thus used in our meta-analyses. Exposures to electromagnetic fields were concerned in 12 publications. The weighted relative risk estimate was 1.35 (95% confidence interval: 1.08-1.70). Exposure to pesticides or other chemicals resulted in the statistically significant relative risk 1.5 while exposure to metals involved no increase of risk. A high degree of work complexity (especially in relation to people) and long education were both protective against Alzheimer’s disease. Based on ten studies the weighted relative risk was 0.47 (95% CI: 0.35-0.63). Both work-related risk factors and protective factors are discussed in relation to possible pathophysiological mechanisms.

Place, publisher, year, edition, pages
Open Access ebooks , 2018.
Keywords [en]
Epidemiology; Electromagnetic fields; Pesticides; Chemicals, Metals; Work complexity; Education.
National Category
Medical and Health Sciences Neurology Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-70399ISBN: 978-93-87500-26-6 (electronic)OAI: oai:DiVA.org:oru-70399DiVA, id: diva2:1267133
Available from: 2018-11-30 Created: 2018-11-30 Last updated: 2018-12-05Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

http://openaccessebooks.com/alzheimers-disease-treatment/alzheimers-disease-and-occupational-exposures-a-systematic-literature-review-and-meta-analyses.pdf

Authority records BETA

Gunnarsson, Lars-GunnarBodin, Lennart

Search in DiVA

By author/editor
Gunnarsson, Lars-GunnarBodin, Lennart
By organisation
School of Medical SciencesÖrebro University School of Business
Medical and Health SciencesNeurologyOccupational Health and Environmental Health

Search outside of DiVA

GoogleGoogle Scholar

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 402 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf