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Distinct transcriptional response of Caenorhabditis elegans to different exposure routes of perfluorooctane sulfonic acid
Örebro University, School of Science and Technology. (The Life Science Center-Biology)
Örebro University, School of Science and Technology. (Man-Technology-Environment Research Centre)ORCID iD: 0000-0002-8679-6841
Örebro University, School of Science and Technology. (The Life Science Center-Biology)ORCID iD: 0000-0001-7336-6335
Örebro University, School of Science and Technology. (Man-Technology-Environment Research Centre)ORCID iD: 0000-0002-6330-789X
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2019 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 168, p. 406-413Article in journal (Refereed) Published
Abstract [en]

Although people are exposed daily to per- and polyfluorinated alkyl substances (PFASs), the biological consequences are poorly explored. The health risks associated with PFAS exposure are currently based on chemical analysis with a weak correlation to potential harmful effects in man and animals. In this study, we show that perfluorooctane sulfonic acid (PFOS), often the most enriched PFAS in the environment, can be transferred via bacteria to higher organisms such as Caenorhabditis elegans. C. elegans nematodes were exposed to PFOS directly in buffer or by feeding on bacteria pretreated with PFOS, and this led to distinct gene expression profiles. Specifically, heavy metal and heat shock associated genes were significantly, although inversely, expressed following the different PFOS exposures. The innate immunity receptor for microbial pathogens, clec-60, was shown for the first time to be down-regulated by PFOS. This is in line with a previous study indicating that PFOS is associated with children's susceptibility to certain infectious diseases. Furthermore, bar-1, a gene associated with various cancers was highly up-regulated only when C. elegans were exposed to PFOS pretreated live bacteria. Furthermore, dead bacterial biomass had higher binding capacity for linear and isomeric PFOS than live bacteria, which correlated to the higher levels of PFOS detected in C. elegans when fed the treated E. toll, respectively. These results reveal new aspects concerning trophic chain transport of PFOS.

Place, publisher, year, edition, pages
Academic Press, 2019. Vol. 168, p. 406-413
Keywords [en]
PFOS biosorption, PFOS isomers, Nematode, Escherichia coli, Food chain
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-71130DOI: 10.1016/j.envres.2018.10.019ISI: 000452938700043PubMedID: 30388497Scopus ID: 2-s2.0-85055720038OAI: oai:DiVA.org:oru-71130DiVA, id: diva2:1276606
Funder
Knowledge Foundation, 20140180
Note

Funding Agency:

Örebro University

Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-01-08Bibliographically approved

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Stylianou, MariosBjörnsdotter, MariaOlsson, Per-ErikEricson Jogsten, IngridJass, Jana

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