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PVC flooring at home and uptake of phthalates in pregnant women
Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm, Sweden.
Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York City New York, USA.
Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.ORCID iD: 0000-0001-7435-9890
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2019 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, Vol. 29, no 1, p. 43-54Article in journal (Refereed) Published
Abstract [en]

Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents' bedrooms as well as potential confounders were collected by postal questionnaires at the same time as the urine samples were taken. Multiple regression modeling by least square geometric mean and weighted quantile sum regression was applied to log-transformed and creatinine-adjusted phthalate metabolite concentrations adjusted for potential confounders from questionnaire data. This study has found significantly higher urinary levels of the BBzP metabolite (MBzP) in pregnant women living in homes with PVC flooring as compared to homes with other flooring materials.

Place, publisher, year, edition, pages
Blackwell Publishing, 2019. Vol. 29, no 1, p. 43-54
Keywords [en]
DINCH, endocrine disrupting chemicals, phthalate, pregnant, PVC flooring, SELMA study
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-71233DOI: 10.1111/ina.12508ISI: 000453742000005PubMedID: 30240038Scopus ID: 2-s2.0-85056330290OAI: oai:DiVA.org:oru-71233DiVA, id: diva2:1276913
Funder
Swedish Asthma and Allergy AssociationVårdal FoundationSwedish Research Council Formas
Note

Funding Agency:

County Council of Värmland

Available from: 2019-01-09 Created: 2019-01-09 Last updated: 2019-01-09Bibliographically approved

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Nånberg, Eewa

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