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Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK.
King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
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2018 (English)In: European Neuropsychopharmacology, ISSN 0924-977X, E-ISSN 1873-7862, Vol. 28, no 10, p. 1059-1088, article id S0924-977X(18)30303-1Article, review/survey (Refereed) Published
Abstract [en]

Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptoms of the disorder and the comorbidities may fluctuate and change over time, and even age of onset in childhood has recently been questioned. Available evidence to date is poor and largely inconsistent with regard to the predictors of persistence versus remittance. Likewise, the development of comorbid disorders cannot be foreseen early on, hampering preventive measures. These facts call for a lifespan perspective on ADHD from childhood to old age. In this selective review, we summarise current knowledge of the long-term course of ADHD, with an emphasis on clinical symptom and cognitive trajectories, treatment effects over the lifespan, and the development of comorbidities. Also, we summarise current knowledge and important unresolved issues on biological factors underlying different ADHD trajectories. We conclude that a severe lack of knowledge on lifespan aspects in ADHD still exists for nearly every aspect reviewed. We encourage large-scale research efforts to overcome those knowledge gaps through appropriately granular longitudinal studies.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 28, no 10, p. 1059-1088, article id S0924-977X(18)30303-1
Keywords [en]
Adult-onset ADHD, Cognitive impairment, Comorbidity, Developmental trajectory, Genetics, Treatment
National Category
Medical and Health Sciences Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-71729DOI: 10.1016/j.euroneuro.2018.08.001ISI: 000445764300001PubMedID: 30195575Scopus ID: 2-s2.0-85052888875OAI: oai:DiVA.org:oru-71729DiVA, id: diva2:1281850
Funder
German Research Foundation (DFG), CRC 1193
Note

Funding Agencies:

European Community 

Netherlands Organization for Scientific Research (NWO) 

Vici Innovation Program 

BMBF (BipoLife)

Hungarian Brain Research Program 

1 + 3 PhD studentship - MRC Social, Genetic & Developmental Psychiatry Centre, King's College London 

Spanish "Ministerio de Economia y Competitividad"

AGAUR, "Generalitat de Catalunya" 

Instituto de Salud Carlos III 

Agencia de Gestiod'Ajuts Universitaris i de Recerca-AGAUR 

Generalitat de Catalunya 

Departament de Salut 

Instituto de Salud Carlos III, Ministerio de Economia, Industria y Competitividad, Spain 

NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation 

Available from: 2019-01-23 Created: 2019-01-23 Last updated: 2019-01-29Bibliographically approved

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