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Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2019 (English)In: Psychological Medicine, ISSN 0033-2917, E-ISSN 1469-8978, Vol. 49, no 7, p. 1166-1173Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.

METHODS: We assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.

RESULTS: Heritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.

CONCLUSIONS: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.

Place, publisher, year, edition, pages
Cambridge University Press, 2019. Vol. 49, no 7, p. 1166-1173
Keywords [en]
ADHD, alcohol dependence, anorexia nervosa, autism spectrum disorders, bipolar disorder, genes, heritability, major depressive disorder, obsessive compulsive disorder, schizophrenia
National Category
Psychiatry Psychology
Identifiers
URN: urn:nbn:se:oru:diva-71743DOI: 10.1017/S0033291718002039ISI: 000474921600011PubMedID: 30221610Scopus ID: 2-s2.0-85053674930OAI: oai:DiVA.org:oru-71743DiVA, id: diva2:1281861
Funder
Wellcome trust, WT 088827/Z/09
Note

Funding Agencies:

Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM)  340-2013-5867

NIMH  U01 MH109528 

UK Medical Research Council  MR/L010305/1  MR/L011794/1 

Lundbeck Foundation  R102-A9118  R155-2014-1724 

Stanley Medical Research Institute  

European Research Council  294838 

Aarhus University  

Netherlands Organization for Scientific Research  NWO VICI 453-14-005 

NIMH NIH HHS  U01 MH109536  U01 MH109532  U01 MH109528 

Medical Research Council  MR/L010305/1 

Available from: 2019-01-23 Created: 2019-01-23 Last updated: 2019-07-29Bibliographically approved

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