oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Unmet Medical Needs in Ulcerative Colitis: An Expert Group Consensus
Humanitas Research Hospital, Milan, Italy.
Department of Gastroenterology and Hepatology, Hôpital Saint-Louis, Paris, France.
Zuyderland Medical Center, Sittard and VU University Medical Center, Amsterdam, The Netherlands.
Division of Gastrotenterology, Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Show others and affiliations
2019 (English)In: Digestive Diseases, ISSN 0257-2753, E-ISSN 1421-9875, Vol. 37, no 4, p. 266-283Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The authors aimed to conduct an extensive literature review and consensus meeting to identify unmet needs in ulcerative colitis (UC) and ways to overcome them. UC is a relapsing and remitting inflammatory bowel disease with varied, and changing, incidence rates worldwide. UC has an unpredictable disease course and is associated with a high health economic burden. During 2016 and 2017, a panel of experts was convened to identify, discuss and address areas of unmet need in UC.

METHODS: PubMed and Cochrane Library databases were searched for relevant articles describing studies performed in patients with UC. These findings were used to generate a set of statements relating to unmet needs in UC. Consensus on these statements was then sought from a panel of 9 expert gastroenterologists using a modified Delphi review process that consisted of anonymous surveys followed by live meetings.

RESULTS: In 2 literature reviews, over 5,000 unique records were identified and a total of 138 articles were fully reviewed. These were used to consider 26 areas of unmet need, which were explored in 2 face-to-face meetings, in which the statements were debated and amended, resulting in consensus on 30 final statements. The unmet needs identified were categorised into 7 areas: impact of UC on patients' daily life; importance of early diagnosis and treatment; drawbacks of existing treatments; urgent need for new treatments; and disease-, practice- or patient-focused unmet needs.

CONCLUSIONS: These expert group meetings found a number of areas of unmet needs in UC, which is an important first step in tackling them in the future. Future research and development should be focused in these areas for the management of patients with UC.

Place, publisher, year, edition, pages
S. Karger, 2019. Vol. 37, no 4, p. 266-283
Keywords [en]
Consensus panel, Delphi process, Systematic literature review, Ulcerative colitis, Unmet needs
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-72369DOI: 10.1159/000496739ISI: 000464379500002PubMedID: 30726845OAI: oai:DiVA.org:oru-72369DiVA, id: diva2:1287951
Note

Funding Agencies:

Pfizer Inc.  

Synergy Medical  

Available from: 2019-02-12 Created: 2019-02-12 Last updated: 2019-06-18Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Halfvarson, Jonas

Search in DiVA

By author/editor
Halfvarson, Jonas
By organisation
School of Medical Sciences
In the same journal
Digestive Diseases
Gastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 50 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf