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Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults - the Lifestyle, Biomarkers, and Atherosclerosis study
Örebro University, School of Medical Sciences. Faculty of Medicine and Health, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden; Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.
Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.
Faculty of Medicine and Health, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Health Sciences.ORCID iD: 0000-0003-1067-8627
2019 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 79, no 3, p. 182-187Article in journal (Refereed) Published
Abstract [en]

The primary aim was to appraise the relationship between body fat percentage and the inflammatory markers C-reactive protein (CRP) and orosomucoid in a population of young, non-smoking, healthy, Swedish adults, without any chronic diseases. A secondary aim was to compare whether these associations differed between the women using estrogen contraceptives and those who did not. We assessed the association in linear regression models between body fat percentage based on a bio-impedance measurement and plasma concentrations of CRP and orosomucoid in men and women aged 18-26 years, n = 834. Statistically significant associations were found between body fat percentage and both biomarkers of inflammation, with β coefficients of 0.30 (95% CI 0.24-0.37) and 0.28 (0.22-0.35) for CRP and orosomucoid, respectively (p < .001). Adjustment for established risk factors marginally lowered the effects sizes (partial betas, 0.28 and 0.20, respectively), while the strong statistically significant associations remained. In the female cohort, estrogen and non-estrogen using subpopulations did not significantly differ in the correlations between body fat percentage and the inflammatory biomarkers, even adjusted for established cardiometabolic risk factors. In conclusion, in healthy young adults, higher levels of body fat percentage are associated with elevations in plasma biomarkers of inflammation, suggesting that a systemic inflammatory process, promoting atherosclerosis, may commence already at this early stage in life. CRP and orosomucoid plasma concentrations differed between users and non-users of estrogen contraceptives, but both subgroups showed similar correlations between increasing body fat percentage and increasing plasma concentrations of the biomarkers of inflammation.

Place, publisher, year, edition, pages
Taylor & Francis, 2019. Vol. 79, no 3, p. 182-187
Keywords [en]
C-reactive protein, adiposity, cardiovascular diseases, inflammation, orosomucoid, risk factors
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-72790DOI: 10.1080/00365513.2019.1576219ISI: 000465174400005PubMedID: 30767573Scopus ID: 2-s2.0-85061928996OAI: oai:DiVA.org:oru-72790DiVA, id: diva2:1291820
Funder
AFA Insurance, 130275
Note

Funding Agencies:

Region Örebro County's Research Committee, Örebro, Sweden  OLL-780061 

Nyckelfonden, Örebro, Sweden  OLL-787681 

Available from: 2019-02-26 Created: 2019-02-26 Last updated: 2019-06-19Bibliographically approved

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Pettersson-Pablo, PaulHurtig-Wennlöf, Anita

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