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VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
Department of Neuroscience, Science for Life Laboratory, BMC, Uppsala University, Uppsala, Sweden.
Centre for Clinical Research Västerås, Västmanland County Hospital Västerås, Uppsala University, Uppsala, Sweden.
Örebro University, School of Law, Psychology and Social Work. Department of Psychology, University of Southern California, Los Angeles, USA.ORCID iD: 0000-0001-8768-6954
Centre for Clinical Research Västerås, Västmanland County Hospital Västerås, Uppsala University, Uppsala, Sweden.
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2019 (English)In: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 28, no 10, p. 1329-1340Article in journal (Refereed) Published
Abstract [en]

The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors. The present study determined whether the association of alcohol-related problems with the rs2290045 in the VGLUT2 gene was modified by negative and positive environmental factors. Three samples were included: a clinical sample of 131 adolescents followed from age 17 to 22; a general population sample of 1794 young adults; and a general population sample of 1687 adolescents followed from age 14 to 17. DNA was extracted from saliva and the rs2290045 (T/C) was genotyped. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test. Stressful life events (SLE) and parenting were assessed by questionnaires. Gene-environment interactions were investigated using a dual statistical approach. In all samples (effect sizes 0.6-6.2%), and consistent with the differential susceptibility framework, T carriers exposed to SLE reported more alcohol-related problems if they had experienced poor parenting, and lower alcohol-related problems if they had received supportive parenting. T carriers not exposed to SLE reported higher alcohol-related problems if they had received supportive parenting and lower alcohol-related problems if they had received poor parenting. Among CC carriers, alcohol-related problems did not vary as a function of negative and positive environmental factors. In conclusion, in three samples of youths, alcohol-related problems were associated with an interaction of VGLUT2 rs2290045, SLE, and parenting.

Place, publisher, year, edition, pages
Springer, 2019. Vol. 28, no 10, p. 1329-1340
Keywords [en]
Adolescents, Alcohol, Gene, Glutamate, Stress, VGLUT2
National Category
Psychiatry Substance Abuse
Identifiers
URN: urn:nbn:se:oru:diva-72879DOI: 10.1007/s00787-019-01293-wISI: 000489301800006PubMedID: 30805764Scopus ID: 2-s2.0-85062073264OAI: oai:DiVA.org:oru-72879DiVA, id: diva2:1293263
Funder
Fredrik och Ingrid Thurings StiftelseThe Swedish Brain Foundation, PS2013-0052Forte, Swedish Research Council for Health, Working Life and Welfare, 2015-00897Stiftelsen Söderström - Königska sjukhemmet, SLS-559921Swedish National Board of Health and WelfareÅke Wiberg FoundationSwedish Research Council, 2013-4657 2014-3804 VR: 2015-00495
Note

Funding Agencies:

Alcohol Research Council of the Swedish Alcohol Retailing Monopoly

Lars Hierta's Minne foundation

Lundberg's and Karlsson's foundation

Uppsala and Örebro Regional Research Council

County Council of Västmanland

Swedish Psychiatric Foundation

Research Foundations of Bertil Hallsten and Ahlen

European Union (EU)

INCA 600398 SciLifeLab 

Available from: 2019-03-04 Created: 2019-03-04 Last updated: 2019-11-12Bibliographically approved

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Tuvblad, CatherineAndershed, Anna-KarinAndershed, Henrik

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