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Resistance Training Alone or Combined With N-3 PUFA-Rich Diet in Older Women: Effects on Muscle Fiber Hypertrophy
School of Health Sciences, Örebro University, Sweden.
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-8071-4745
School of Health Sciences, Örebro University, Sweden.
School of Health Sciences, Örebro University, Sweden.
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2019 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 74, no 4, p. 489-494Article in journal (Refereed) Published
Abstract [en]

We aimed to examine cellular and molecular changes in skeletal muscle of recreationally active older women in response to 24 weeks of combined resistance training and N-3 PUFA-rich healthy diet. Sixty-three women (65-70 years) were randomized into resistance training and healthy diet rich in N-3PUFAs (RT-HD), resistance training only (RT) and controls (CON). Fiber type-specific morphological characteristics and gene expression of inflammatory biomarkers and regulators of muscle mass were analyzed in m. vastus lateralis biopsies obtained before the intervention and 4 days after the last training session. Gene expression of the proinflammatory cytokine IL-1β was downregulated (p < .05) and that of the regulator of cellular growth mTOR (p < 0.05) was upregulated in skeletal muscle of RT-HD only. There was also a significant hypertrophy of fast type IIA muscle fibers in RT-HD only (+23%, p < .05). In conclusion, resistance training combined to an N-3 PUFA-rich healthy diet but not alone triggers local anti-inflammatory and growth responses, favoring skeletal muscle hypertrophy in already recreationally active older women.

Place, publisher, year, edition, pages
Oxford University Press, 2019. Vol. 74, no 4, p. 489-494
Keywords [en]
Exercise, Inflammation, Muscles, Sarcopenia, mTOR
National Category
Physiology Geriatrics
Identifiers
URN: urn:nbn:se:oru:diva-73206DOI: 10.1093/gerona/gly130ISI: 000462601700007PubMedID: 30052800Scopus ID: 2-s2.0-85062936694OAI: oai:DiVA.org:oru-73206DiVA, id: diva2:1296887
Note

Funding Agency:

Swedish National Center for Research in Sports  P2012/102  P2014-0117

Available from: 2019-03-18 Created: 2019-03-18 Last updated: 2019-06-19Bibliographically approved

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Ponsot, ElodieKadi, Fawzi

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