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Modified lipoproteins in periodontitis: a link to cardiovascular disease?
Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Örebro University, School of Medical Sciences.
Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Centre for Oral Rehabilitation, Public Dental Health Care County Council of Östergötland, Linköping, Sweden.
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2019 (English)In: Bioscience Reports, ISSN 0144-8463, E-ISSN 1573-4935, Vol. 39, no 3, article id BSR20181665Article in journal (Refereed) Published
Abstract [en]

There is a strong association between periodontal disease and atherosclerotic cardiovascular disorders. A key event in the development of atherosclerosis is accumulation of modified lipoproteins within the arterial wall. We hypothesize that patients with periodontitis have an altered lipoprotein profile towards an atherogenic form. Therefore, this study aims at identifying modifications of plasma lipoproteins in periodontitis. Lipoproteins from ten female patients with periodontitis and gender- and age-matched healthy controls were isolated by density-gradient-ultracentrifugation. Proteins were separated by two-dimensional gel-electrophoresis and identified by map-matching or by nano-liquid chromatography followed by mass spectrometry. ApoA-I methionine oxidation, Oxyblot, total antioxidant capacity and a multiplex of 71 inflammation-related plasma proteins were assessed.Reduced levels of apoJ, phospholipid transfer protein, apoF, complement C3, paraoxonase 3 and increased levels of alpha-1-antichymotrypsin, apoA-II, apoC-III were found in HDL from the patients. In LDL/VLDL, the levels of apoL-1 and platelet-activating factor acetylhydrolase as well as apo-B fragments were increased. Methionine oxidation of apoA-I was increased in HDL and showed a relationship with periodontal parameters. Alpha-1 antitrypsin and alpha-2-HS glycoprotein were oxidised in LDL/VLDL and antioxidant capacity was increased in the patient group. 17 inflammation-related proteins were important for group separation with the highest discriminating proteins identified as IL-21, Fractalkine, IL-17F, IL-7, IL-1RA and IL-2.Patients with periodontitis have an altered plasma lipoprotein profile, defined by altered protein levels as well as posttranslational and other structural modifications towards an atherogenic form, which supports a role of modified plasma lipoproteins as central in the link between periodontal and cardiovascular disease (CVD).

Place, publisher, year, edition, pages
Portland Press, 2019. Vol. 39, no 3, article id BSR20181665
Keywords [en]
Lipoproteins, nLC-MS/MS, periodontal microbiota, periodontitis, two-dimensional gel electrophoresis
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-73198DOI: 10.1042/BSR20181665ISI: 000465453700016PubMedID: 30842338Scopus ID: 2-s2.0-85063936955OAI: oai:DiVA.org:oru-73198DiVA, id: diva2:1297233
Funder
Knowledge Foundation, Dnr20150037Magnus Bergvall Foundation
Note

Funding Agency:

Foundation Längmanska Kulturfonden

Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-06-19Bibliographically approved

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Bengtsson, TorbjörnPalm, EleonorLönn, Johanna

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