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Inflammatory response and Patient characteristics in Open and Laparoscopic Sigmoidectomy
Örebro University, School of Medical Sciences.
2019 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Background and Aims

Colorectal cancer is the third most common type of cancer in Sweden, male and female, with 6500 (4500 colonic/2000 rectal) new cases each year. Surgery remains the treatment of choice. Previous studies show that laparoscopic procedure may lead to fewer complications, shorter postoperative stays and a lesser inflammatory response compared to open procedure. The study examines whether laparoscopic surgery of sigmoid cancer differs from open surgery, regarding inflammatory response through analysis of routine measurements. It also investigates differences in peri- and postoperative quality data from Swedish Colorectal Cancer Registry.

Material and Methods

307 consecutive patients underwent surgical sigmoidectomy from February 2007- February 2017, from which elective patients with sigmoid cancer were included. Pre-and postoperative CRP and postoperative WBC, Haemoglobin and Creatinine were collected from medical records at the Department of Surgery, Örebro University hospital. Patient related and perioperative variables were collected from SCRCR (e.g. postoperative stay, bleeding, complications).

Results

158 patients fulfilled the inclusion criteria. There was a marked increase in CRP postoperative in both laparoscopic (89) and open (69) groups, but no significant difference comparing the groups. There was a significant difference in perioperative bleeding (p<0.05) and length of stay (p<0.05).

Conclusion

Sigmoidectomy, laparoscopic or open, cause an increase in CRP. No significant difference in inflammatory response was noted between the groups. Patients undergoing laparoscopic, compared to open sigmoidectomy has: less perioperative bleeding, shorter postoperative stay and a longer duration of surgery, like previous studies.

Place, publisher, year, edition, pages
2019.
Keywords [en]
laparoscopic sigmoidectomy, sigmoid cancer, CRP, SCRCR, inflammatory response
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-73270OAI: oai:DiVA.org:oru-73270DiVA, id: diva2:1298225
Subject / course
Medicine
Supervisors
Examiners
Available from: 2019-03-22 Created: 2019-03-22 Last updated: 2019-03-22Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf