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Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh; Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
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2019 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 668, p. 1004-1012Article in journal (Refereed) Published
Abstract [en]

Arsenic (As) toxicity and diabetes mellitus (DM) are emerging public health concerns worldwide. Although exposure to high levels of As has been associated with DM. whether there is also an association between low and moderate As exposure and DM remains unclear. We explored the dose-dependent association between As exposure levels and hyperglycemia, with special consideration of the impact of demographic variables, in 641 subjects from rural Bangladesh. The total study participants were divided into three groups depending on their levels of exposure to As in drinking water (low, moderate and high exposure groups). Prevalence of hyperglycemia, including impaired glucose tolerance (IGT) and DM was significantly associated with the subjects' drinking water arsenic levels. Almost all exposure metrics (As levels in the subjects' drinking water, hair and nails) showed dose-dependent associations with the risk or hyperglycemia, IGT and DM. Among the variables considered, sex, age, and BMI were found to be associated with higher risk of hyperglycemia. IGT and DM. In sex-stratified analyses, As exposure showed a clearer pattern of dose-dependent risk for hyperglycemia in females than males. Finally, drinking water containing low-to-moderate levels of As (50.01-150 mu g/L) was found to confer a greater risk of hyperglycemia than safe drinking water (As <= 10 mu g/L). Thus the results suggested that As exposure was dose-dependently associated with hyperglycemia, especially in females.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 668, p. 1004-1012
Keywords [en]
Arsenic, Hyperglycemia, Impaired glucose tolerance, Diabetes, Bangladesh
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-73755DOI: 10.1016/j.scitotenv.2019.03.029ISI: 000462776800092PubMedID: 31018442Scopus ID: 2-s2.0-85062716791OAI: oai:DiVA.org:oru-73755DiVA, id: diva2:1305260
Note

Funding Agencies:

Ministry of Science and Technology, Government of the People's Republic of Bangladesh  39.009.006.01.00.042.2012-2013/ES-21/558 

National Institutes of Health  R01 CA129560 

MUSC Bridge funding  20441 

Center for Global Health  20438 

JSPS KAKENHI program  16H05834 

Rajshahi University  5/52/RU/Science-13/17-18 

Available from: 2019-04-16 Created: 2019-04-16 Last updated: 2019-06-13Bibliographically approved

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Rahman, Aminur

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