The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Number of Authors: 2232019 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 34, no 3, p. 279-300Article in journal (Refereed) Published
Abstract [en]
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Place, publisher, year, edition, pages
Springer, 2019. Vol. 34, no 3, p. 279-300
Keywords [en]
Genetics, Consortium, Childhood traits and disorders, Longitudinal
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-73963DOI: 10.1007/s10654-019-00502-9ISI: 000463834200009PubMedID: 30887376Scopus ID: 2-s2.0-85063253340OAI: oai:DiVA.org:oru-73963DiVA, id: diva2:1307749
Note
Funding Agencies:
European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 721567
European Union's Horizon 2020 research and innovation programme 633595 733206
Sir Henry Dale Fellowship (Wellcome Trust)
Sir Henry Dale Fellowship (Royal Society) WT104150
American Diabetes Association 1-17-PDF-077
Dutch Science Organization (ZonMW-VENI Grant) 916.14.023
Australian National Health and Medical Research Council Early Career Fellowship APP1104818
Gene-Diet Interactions in Obesity (GENDINOB) project
National Institute of Health Research
European Research Council 323195 SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC
Children's Hospital of Philadelphia Endowed Chair in Genomic Research
National Institute for Health Research (NIHR) Senior Investigator Award NF-SI-0611-10219
German Research Society, German Ministry of Education and Research
American Diabetes Association (ADA) Pathway Program Accelerator Early Investigator Award 1-15-ACE-26
Helse Vest 23929
Bergen Forskningsstiftelse
KG Jebsen Foundation
University of Bergen
Academy of Finland Research Professor program 265240 263278
University of Queensland Development Fellowship UQFEL1718945
Li Ka Shing Foundation
WT-SSI/John Fell funds
NIHR Biomedical Research Centre, Oxford
Widenlife
NIH 5P50HD028138-27
NHMRC Senior Reseach Fellowship APP1103623
Career development fellowship 20308
Wellcome Trust WT098395 WT098051 WT205915 098051
National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London
European Union's Horizon 2020 research
European Union FP7-IDEAS-ERC Advanced Grant (GEPIDIAB) ERC-AG -ERC-294785
European Union FP7-IDEAS-ERC innovation programme (DYNAhealth) H2020-PHC-2014-633595
CRUK C18281/A19169
NHMRC Practitioner Fellowship Grant APP1105807
European Regional Development Fund (ERDF)
European Social Fund (ESF)
Convergence Programme for Cornwall
Isles of Scilly
Diabetes Research and Wellness Foundation Non-Clinical Fellowship
Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya 2015 FI_B 00636
ZonMW TOP 40-00812-98-11010
MRC Human Genetics Unit quinquennial programme "QTL in Health and Disease"
Diabetes UK RD Lawrence fellowship 17/0005594
BBMRI-NL CP2013-50
Novo Nordisk Foundation 12955
Oak Foundation Fellowship
European Research Council (ERC)
KG Jebsen
European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant 669545
US National Institute of Health R01 DK10324
UK Medical Research Council MC_UU_00011/6
Wellcome Trust GWAS grant WT088806
NIHR Senior Investigator Award NF-SI-0611-10196
NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol
UK Medical Research Council Unit MC_UU_12013_5 MC_UU_12013_4
University of Bristol NIHR Biomedical Research Centre (BRC) 202802/Z/16/Z WT 102215/2/13/2
CRUK Integrative Cancer Epidemiology Programme C18281/A19169
Netherlands Organization for Health Research and Development (NWO) ZonMw-VIDI 016.136.361
European Research Council Consolidator Grant ERC-2014-CoG-648916
Australian Research Council Future Fellowship FT130101709
NHMRC Senior Research Fellowship GNT1137714
Daniel B. Burke Endowed Chair for Diabetes Research
Spinozapremie NWO-56-464-14192
Royal Netherlands Academy of Science Professor Award PAH/6635
NIHR NF-SI-0617-10090
Wellcome 090532 098381 203141
R01 HD056465
2019-04-292019-04-292023-12-08Bibliographically approved