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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Child Health Research Centre, University of Queensland, Brisbane QLD, Australia; Child and Youth Mental Health Service, Children’s Health Queensland Hospital and Health Service, Brisbane QLD, Australia; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID iD: 0000-0002-6218-0428
Örebro University, School of Medical Sciences. Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.;Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.;Orebro Univ, Sch Med Sci, Orebro, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LE, England.;RIKEN, Ctr Integrat Med Sci, Lab Endocrinol Metab & Kidney Dis, Yokohama, Kanagawa 2300045, Japan.;Orebro Univ, Sch Med Sci, Orebro, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..ORCID iD: 0000-0002-6851-3297
Univ Leipzig, Pediat Res Ctr, Dept Womens & Child Hlth, Leipzig, Germany; Univ Leipzig, IFB Adipos Dis, Leipzig, Germany; Univ N Carolina, Dept Genet, Chapel Hill NC, USA; Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands; Erasmus MC, Child & Adolescent Psychiat, Rotterdam, Netherlands; Harvard Univ, Social & Behav Sci, Harvard TH Chan Sch Publ Hlth, Boston MA, USA.
Number of Authors: 2232019 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 34, no 3, p. 279-300Article in journal (Refereed) Published
Abstract [en]

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.

Place, publisher, year, edition, pages
Springer, 2019. Vol. 34, no 3, p. 279-300
Keywords [en]
Genetics, Consortium, Childhood traits and disorders, Longitudinal
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-73963DOI: 10.1007/s10654-019-00502-9ISI: 000463834200009PubMedID: 30887376OAI: oai:DiVA.org:oru-73963DiVA, id: diva2:1307749
Note

Funding Agencies:

European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant  721567 

European Union's Horizon 2020 research and innovation programme  633595  733206 

Sir Henry Dale Fellowship (Wellcome Trust)  

Sir Henry Dale Fellowship (Royal Society)  WT104150 

American Diabetes Association  1-17-PDF-077 

Dutch Science Organization (ZonMW-VENI Grant)  916.14.023 

Australian National Health and Medical Research Council Early Career Fellowship  APP1104818 

Gene-Diet Interactions in Obesity (GENDINOB) project  

National Institute of Health Research  

European Research Council  323195 SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC 

Children's Hospital of Philadelphia Endowed Chair in Genomic Research  

National Institute for Health Research (NIHR) Senior Investigator Award  NF-SI-0611-10219 

German Research Society, German Ministry of Education and Research  

American Diabetes Association (ADA) Pathway Program Accelerator Early Investigator Award  1-15-ACE-26 

Helse Vest  23929 

Bergen Forskningsstiftelse  

KG Jebsen Foundation  

University of Bergen  

Academy of Finland Research Professor program  265240  263278 

University of Queensland Development Fellowship  UQFEL1718945 

Li Ka Shing Foundation  

WT-SSI/John Fell funds  

NIHR Biomedical Research Centre, Oxford  

Widenlife  

NIH  5P50HD028138-27 

NHMRC Senior Reseach Fellowship  APP1103623 

Career development fellowship  20308 

Wellcome Trust  WT098395  WT098051  WT205915  098051 

National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London  

European Union's Horizon 2020 research  

European Union FP7-IDEAS-ERC Advanced Grant (GEPIDIAB)  ERC-AG -ERC-294785 

European Union FP7-IDEAS-ERC innovation programme (DYNAhealth)  H2020-PHC-2014-633595 

CRUK  C18281/A19169 

NHMRC Practitioner Fellowship Grant  APP1105807 

European Regional Development Fund (ERDF)  

European Social Fund (ESF)  

Convergence Programme for Cornwall  

Isles of Scilly  

Diabetes Research and Wellness Foundation Non-Clinical Fellowship  

Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya  2015 FI_B 00636 

ZonMW  TOP 40-00812-98-11010 

MRC Human Genetics Unit quinquennial programme "QTL in Health and Disease"  

Diabetes UK RD Lawrence fellowship  17/0005594 

BBMRI-NL  CP2013-50 

Novo Nordisk Foundation  12955 

Oak Foundation Fellowship  

European Research Council (ERC)  

KG Jebsen  

European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant  669545 

US National Institute of Health  R01 DK10324 

UK Medical Research Council  MC_UU_00011/6 

Wellcome Trust GWAS grant  WT088806 

NIHR Senior Investigator Award  NF-SI-0611-10196 

NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol  

UK Medical Research Council Unit  MC_UU_12013_5  MC_UU_12013_4 

University of Bristol NIHR Biomedical Research Centre (BRC)  202802/Z/16/Z  WT 102215/2/13/2 

CRUK Integrative Cancer Epidemiology Programme  C18281/A19169 

Netherlands Organization for Health Research and Development (NWO)  ZonMw-VIDI 016.136.361 

European Research Council Consolidator Grant  ERC-2014-CoG-648916 

Australian Research Council Future Fellowship  FT130101709 

NHMRC Senior Research Fellowship  GNT1137714 

Daniel B. Burke Endowed Chair for Diabetes Research  

Spinozapremie  NWO-56-464-14192 

Royal Netherlands Academy of Science Professor Award  PAH/6635 

NIHR  NF-SI-0617-10090 

Wellcome  090532  098381  203141   

R01 HD056465 

Available from: 2019-04-29 Created: 2019-04-29 Last updated: 2019-04-29Bibliographically approved

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