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Does Fatty Acid Composition in Subcutaneous Adipose Tissue Differ between Patients with Alzheimer's Disease and Cohabiting Proxies?
Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.
Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.
Department of Public Health and Caring Sciences, Division of Geriatrics, Uppsala University, Uppsala, Sweden.
Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden; Department of Geriatrics, Karolinska University Hospital, Huddinge, Sweden.
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2018 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 61, no 2, p. 515-519Article in journal (Refereed) Published
Abstract [en]

Low tissue levels of the major marine ω3 fatty acids (FAs) DHA and EPA are found in Alzheimer's disease (AD). We investigated if healthy proxies to AD patients have higher levels of these ω3 FAs. We observed lower levels of EPA and DHA in subcutaneous adipose tissue biopsies from 64 AD patients compared with 16 cognitively healthy proxies. No significant difference was observed when pairwise comparisons were made between a subset of 16 AD patients and their co-habiting proxies. Larger studies are needed to replicate these findings and to determine if they could depend on FA intake or differences in metabolism.

Place, publisher, year, edition, pages
IOS Press, 2018. Vol. 61, no 2, p. 515-519
Keywords [en]
Alzheimer’s disease, DHA, EPA, cognition, cohabitants, subcutaneous adipose tissue, ω3 fatty acids
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-74038DOI: 10.3233/JAD-170359ISI: 000422844100004PubMedID: 29154271Scopus ID: 2-s2.0-85038834560OAI: oai:DiVA.org:oru-74038DiVA, id: diva2:1313782
Note

Funding agencies:

Stockholm County Council

Karolinska Institutet

Medical Research Council

Funds of Capio

Demensförbundet

Gamla Tjänarinnor

Swedish Alzheimer Foundation

Odd Fellow

Swedish Nutrition Foundation

Gun och Bertil Stohnes Stiftelse

Swedish Society of Physicians

Lion's Sweden

Available from: 2019-05-06 Created: 2019-05-06 Last updated: 2019-06-18Bibliographically approved

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Freund-Levi, Yvonne

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